Evidence map›Paper›PMID 33447591›Full record

ArticleOcular oncology and pathology2020

Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase.

David Van Ly, Duo Wang, Robert Max Conway, Michael Giblin, Sharron Liang, Robyn Lukeis, Li-Anne Lim, Luke Hesson, Svetlana Cherepanoff

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular oncology and pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

David Van LyAnatomical Pathology, SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia.
Duo WangAnatomical Pathology, SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia.
Robert Max ConwaySave Sight Institute, The University of Sydney, Sydney, New South Wales, Australia.
Michael GiblinSydney Eye Hospital, Sydney, New South Wales, Australia.
Sharron LiangAnatomical Pathology, SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia.
Robyn LukeisAnatomical Pathology, SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia.
Li-Anne LimSydney Eye Hospital, Sydney, New South Wales, Australia.
Luke HessonKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Svetlana CherepanoffAnatomical Pathology, SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia.
St Vincent's Hospital Sydney · AUSydney Hospital · AUGarvan Institute of Medical Research · AUThe University of Notre Dame Australia · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.

Indexed as

CholesterolHMG-CoA reductaseLipidsStatinUveal melanoma

Identifiers

PMID33447591
PMCPMC7772867
OpenAlexW3092157436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.