ReviewGland surgery2020
Ultra-high frequency ultrasound (UHFUS) applications in Sjogren syndrome: narrative review and current concepts.
Review in Gland surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Ultra-high frequency ultrasound of labial salivary glands in Sjögren's disease: diagnostic accuracy and patient stratification.RMD open · 2026Article
- Oral Dysaesthetic and Perceptual Disorder, A Distinct Subset of Chronic Orofacial Pain Without Burning Symptoms: A Case-Control Study.Journal of oral rehabilitation · 2025Article
- Clinical Features and Patient-Reported Outcomes in a Cohort of Patients with Sjögren's Disease.Journal of clinical medicine · 2025Article
- Imaging the Micron: New Directions in Diagnosis with Ultra-High-Frequency Ultrasound.Diagnostics (Basel, Switzerland) · 2024Article
- OHIP-14 Scores in Patients with Sjögren's Syndrome Compared to Sicca Syndrome: A Systematic Review with Meta-Analysis.International journal of dentistry · 2024Review
- The Reliability of Ultrasonographic Assessment of Depth of Invasion: A Systematic Review with Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren's Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Salivary Complaints in Burning Mouth Syndrome: A Cross Sectional Study on 500 Patients.Journal of clinical medicine · 2023Article
- Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren's Disease: A Preliminary Study.Diagnostics (Basel, Switzerland) · 2023Article
- Reliability of OMERACT Scoring System in Ultra-High Frequency Ultrasonography of Minor Salivary Glands: Inter-Rater Agreement Study.Journal of imaging · 2022Article
- Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature.Journal of clinical medicine · 2021Review
- Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS.Journal of inflammation research · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary Sjogren's syndrome (SS) is a systemic autoimmune chronic inflammatory disease with predominant involvement of the exocrine glands, particularly the salivary glands (SGs). The role of salivary glands ultrasound (SGUS) in the work-up of patients with primary Sjogren syndrome (SS) is progressively increasing due to its useful support in diagnosis and follow-up as a widely available, repeatable, non-invasive and safe technique. Although SGUS is not yet included in the dominant primary SS classification, several studies supported its inclusion in the American College of Rheumatology/European League Against Rheumatism criteria. In this context, a novel imaging technique, ultra-high frequency ultrasound (UHFUS), is being explored. Compared to the frequencies used in conventional ultrasound (US) (up to 22 MHz), UHFUS operates with higher frequencies (30-100 MHz) allowing for outstanding image resolution, up to 30 µm. UHFUS permits the scan of both major and minor SGs, opening new avenues for the integration of tissue and imaging biomarkers. Although further studies are needed to confirm its role, this novel imaging technique might lead to several potential improvements, including earlier diagnosis, reduction of unnecessary and inadequate biopsies and better management and follow-up of patients with primary SS.
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