ArticleGland surgery2020
The decreased expression of hsa_circ_0043278 and its relationship with clinicopathological features of breast cancer.
Article in Gland surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- CircRNAs as promising biomarker in diagnosis of breast cancer: An updated meta-analysis.Journal of clinical laboratory analysis · 2021Pooled it
- Circular RNA-mediated miRNA sponge & RNA binding protein in biological modulation of breast cancer.Non-coding RNA research · 2024Review
- Circular RNAs: biology and clinical significance of breast cancer.RNA biology · 2023Review
- Article
- Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway.BMC cancer · 2021Article
- Exploring the Clinical Transformation of circRNA as a Biomarker in Breast Cancer.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer is one of the most significant causes of death in women around the world. Circular RNAs (circRNAs), which are a novel class of conserved RNA molecules, are involved in the occurrence and development of various diseases, especially malignancies; however, researchers rarely report their roles in human breast cancer.
methodsIn the present study, the differentially expressed levels of circRNAs in human breast cancer tissues and paired noncancerous tissues were screened by circRNA microarray. Hsa_circ_0043278 was downregulated 43-fold in breast cancer and was selected for further analysis. The expression of hsa_circ_0043278 was verified in breast cancer specimens and paired noncancerous tissues by quantitative reverse transcription polymerized chain reaction (qRT-PCR) technique. The relationship between the expression of hsa_circ_0043278 and the clinicopathological features was analyzed.
resultsAmong the 520 differentially expressed circRNAs, 292 significantly upregulated circRNAs and 228 downregulated circRNAs in the breast cancer tissues compared with the paired noncancerous tissues. The area under the receiver operating characteristic (ROC) curve of hsa_circ_0043278 was 0.690. The results of the bioinformatics prediction showed five target miRNAs that might be sponged by hsa_circ_0043278. The expression of hsa_circ_0043278 was associated with lymph node metastasis and histological type of the patient. Patients with lymph node metastasis have tumors with significantly downregulated expression of hsa_circ_0043278 (P=0.0201).
conclusionsOur results suggest that hsa_circ_0043278 is downregulated and may play a key role in human breast cancer.
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Registered trials
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