ArticleSAGE open medical case reports2020
Statin-associated anti-HMGCR immune-mediated necrotizing myopathy with dermatomyositis-like features: A case report.
Article in SAGE open medical case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Rare cutaneous manifestations of statin-induced anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase immune-mediated necrotizing myopathy.JAAD case reports · 2026Article
- Anti-HMGCR positive immune-mediated necrotizing myopathy with associated neutrophilic urticarial dermatosis: A case report.JAAD case reports · 2025Article
- Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase immune-mediated necrotizing myopathy with a CD68+ lymphohistiocytic cutaneous eruption.JAAD case reports · 2025Article
- Nailfold capillaroscopy in myositis: A case series.SAGE open medical case reports · 2025Article
- Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy.BMC immunology · 2024Article
- A Challenging Inflammatory Myopathy Case-Report: Dermatomyositis-Like Rash in an Anti-HMGCR Positive Patient with an Uncertain Muscle Histology.Mediterranean journal of rheumatology · 2023Article
- Challenges in the diagnosis and management of immune-mediated necrotising myopathy (IMNM) in a patient on long-term statins.Rheumatology international · 2023Review
- The prevalence and clinical characteristics of anti-HMGCR (anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase) antibodies in idiopathic inflammatory myopathy: an analysis from the MyoCite registry.Rheumatology international · 2022Article
- Atypical presentation of anti-HMGCR myopathy.BMJ case reports · 2021Article
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Authors and funding
7 authors.
Funding
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Abstract
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) immune-mediated necrotizing myopathy is a subtype of idiopathic inflammatory myopathy which may be associated with statin exposure. It presents with severe proximal muscle weakness, high creatine kinase levels and muscle fiber necrosis. Treatment with intravenous immunoglobulins and immunosuppressants is often necessary. This entity is not commonly known among dermatologists as there are usually no extramuscular manifestations. We report a rare case of statin-associated anti-HMGCR immune-mediated necrotizing myopathy with dermatomyositis-like cutaneous features. The possibility of anti-HMGCR immune-mediated necrotizing myopathy should be considered in patients with cutaneous dermatomyositis-like features associated with severe proximal muscle weakness, highly elevated creatine kinase levels and possible statin exposure. This indicates the importance of muscle biopsy and specific autoantibody testing for accurate diagnosis, as well as significant therapeutic implications.
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