Evidence map›Paper›PMID 33447354›Full record

ArticleTherapeutic advances in endocrinology and metabolism2020

Hypomagnesemia in persons with type 1 diabetes: associations with clinical parameters and oxidative stress.

Peter R van Dijk, F Waanders, Jiedong Qiu, Hannah H R de Boer, H van Goor, H J G Bilo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Peter R van DijkDepartment of Endocrinology, University Medical Center, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-9702-6551
F WaandersIsala, Department of Internal Medicine, Zwolle, The Netherlands.
Jiedong Qiu5th Medical Department, Universitätsklinikum Mannheim, Mannheim, Germany.
Hannah H R de BoerDepartment of Endocrinology, University of Groningen, University Medical Center, Groningen, The Netherlands.
H van GoorDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, The Netherlands.
H J G BiloDepartment of Internal Medicine, University of Groningen, University Medical Center, Groningen, The Netherlands.
University Medical Center Groningen · NLHeidelberg University · DEIsala · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong persons with type 1 diabetes mellitus (T1DM) low concentrations of magnesium have been reported. Previous (small) studies also suggested a relation of hypomagnesemia with (poor) glycaemic control and complications. We aimed to investigate the magnitude of hypomagnesemia and the associations between magnesium with parameters of routine T1DM care in a population of unselected outpatients.

methodsAs part of a prospective cohort study, initially designed to measure quality of life and oxidative stress, data from 207 patients with a mean age of 45 [standard deviation (SD) 12] years, 58% male, diabetes duration 22 [interquartile range (IQR) 16, 31] years and glycated haemoglobin (HbA1c) of 60 (SD 11) mmol/mol [7.6 (SD 1.0)%] were examined. Hypomagnesemia was defined as a concentration below <0.7 mmol/l.

resultsMean magnesium concentration was 0.78 (SD 0.05) mmol/l. A deficiency was present in 4.3% of participants. Among these persons, mean concentration was 0.66 (SD 0.03) mmol/l. There was no correlation between magnesium and HbA1c at baseline (

conclusionIn this cohort of T1DM outpatients, the presence of hypomagnesemia was infrequent and, if present, relative mild. Magnesium was not associated with glycaemic control nor with presence of micro- and macrovascular complications. Although these results need confirmation, in particular the negative association of magnesium with free thiols, this suggests that hypomagnesemia is not a relevant topic in routine care for people with T1DM.

Indexed as

glycaemiainsulinmagnesiumoxidative stresstype 1 diabetes

Identifiers

PMID33447354
PMCPMC7780304
OpenAlexW3116374502

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.