ArticleCommunicative & integrative biology2020
Adhesion stimulates Scar/WAVE phosphorylation in mammalian cells.
Article in Communicative & integrative biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Unravelling cell migration: defining movement from the cell surface.Cell adhesion & migration · 2022Review
- AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment.Frontiers in molecular biosciences · 2022Article
- Extracellular Signalling Modulates Scar/WAVE Complex Activity through Abi Phosphorylation.Cells · 2021Article
- The WAVE complex associates with sites of saddle membrane curvature.The Journal of cell biology · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Scar/WAVE complex catalyzes the protrusion of pseudopods and lamellipods, and is therefore a principal regulator of cell migration. However, it is unclear how its activity is regulated, beyond a dependence on Rac. Phosphorylation of the proline-rich region, by kinases such as Erk2, has been suggested as an upstream activator. We have recently reported that phosphorylation is not required for complex activation. Rather, it occurs after Scar/WAVE has been activated, and acts as a modulator. Neither chemoattractant signaling nor Erk2 affects the amount of phosphorylation, though in Dictyostelium it is promoted by cell-substrate adhesion. We now report that cell-substrate adhesion also promotes Scar/WAVE2 phosphorylation in mammalian cells, suggesting that the process is evolutionarily conserved.
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Registered trials
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