Evidence map›Paper›PMID 33447308›Full record

ReviewJournal of clinical medicine research2020

Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review.

Vandan D Upadhyaya, Steven Douedi, Brandon Garcia, Jimmy Gonzalez, Ndausung Udongwo, Juanqin Wei, Qiang Nai, Arif Asif, Shuvendu Sen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. GPCR Biased Signaling in Cancer.Handbook of experimental pharmacology · 2026
    Review
  3. Cholinergic Mechanisms in Gastrointestinal Neoplasia.International journal of molecular sciences · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vandan D UpadhyayaDepartment of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA.
Steven DouediDepartment of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA.
Brandon GarciaDepartment of Pharmacy, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA.
Jimmy GonzalezErnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Ndausung UdongwoDepartment of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA.
Juanqin WeiRobert Wood Johnson University Hospital - Somerset, Somerville, NJ, USA.
Qiang NaiMassachusetts General Cancer Center, Cooley Dickinson Hospital, Northampton, MA, USA.
Arif AsifDepartment of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA.
Shuvendu SenDepartment of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.

Indexed as

Beta-adrenergic pathwayBeta-blockersCancerPancreatic adenocarcinoma

Identifiers

PMID33447308
PMCPMC7781287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.