ArticleNature and science of sleep2021
Striatal Dopaminergic Deficit and Sleep in Idiopathic Rapid Eye Movement Behaviour Disorder: An Explorative Study.
Article in Nature and science of sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Sex differences in alpha-synucleinopathies: a systematic review.Frontiers in neurology · 2023Pooled it
- Predictors of dream enactment behavior among medical students: The case of the University of Gondar, Ethiopia.PloS one · 2022Trial
- Unraveling sleep dysfunction in progressive supranuclear palsy: a pilot study on the role of periodic limb movements in sleep and insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Association between sleep duration and depressive symptoms among older adults in China: a national cross-sectional study.Frontiers in psychiatry · 2026Article
- Creativity and REsilience Through Arts, Technology and Emotions: A Pilot Study on the Feasibility and Validity of the CREATE Platform.Brain sciences · 2025Article
- Case Report: REM sleep without atonia in an adult with pediatric acute-onset neuropsychiatric syndrome: a case study and mechanistic insights.Frontiers in sleep · 2025Article
- Dreaming Characteristics in Non-Rapid Eye Movement Parasomnia and Idiopathic Rapid Eye Movement Sleep Behaviour Disorder: Similarities and Differences.Nature and science of sleep · 2024Article
- Spinocerebellar Ataxia 36 is a Frequent Cause of Hereditary Ataxia in Eastern Spain.Movement disorders clinical practice · 2023Article
- Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.Scientific reports · 2022Article
- RT-QuIC and Related Assays for Detecting and Quantifying Prion-like Pathological Seeds of α-Synuclein.Biomolecules · 2022Review
- Restricted truncal sagittal movements of rapid eye movement behaviour disorder.NPJ Parkinson's disease · 2022Article
- Obstructive sleep apnea and multiple facets of a neuroinflammatory response: a narrative review.Journal of thoracic disease · 2022Review
- Periodic limb movements during sleep: a narrative review.Journal of thoracic disease · 2021Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
introductionIdiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is increasingly recognised as an important precursor disease state of alpha-synucleinopathies. This parasomnia is characterized by a history of recurrent nocturnal dream enactment behaviour, loss of skeletal muscle atonia, and increased phasic muscle activity during REM sleep. Neuroimaging studies of striatal dopamine transporter uptake tracer signaling suggest increasing dopaminergic deficit across the continuum of the alpha-synucleinopathies, with early sleep dysfunction suggestive of early caudate dysfunction. Henceforth, we set out to investigate the relationship between early sleep changes and the striatal dopaminergic availability in iRBD.
methodsTwelve patients with iRBD, who had undergone a video polysomnography and a neuroimaging assessment of striatal dopamine transporter (DaT) uptake tracer signaling, and 22 matched controls who had similarly undergone a video polysomnography were retrospectively identified. Data were statistically analyzed to identify altered sleep parameters and correlate them with striatal dopamine transporter uptake tracer signaling.
resultsThe iRBD patients exhibited an increased number of periodic limb movements during sleep ( DISCUSSION: To the best of our knowledge, this is the first demonstration of a close relationship between dopaminergic availability in striatum and the quality of sleep in iRBD. Taken together, our exploratory findings suggest that subtle but functionally significant striatal changes in early stages of iRBD may contribute to the further shaping of sleep architecture.
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