Evidence map›Paper›PMID 33447083›Full record

ArticleCancer management and research2021

Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms.

Shengming Deng, Zhiyao Fan, Huanyu Xia, Yitao Gong, Yunzhen Qian, Qiuyi Huang, He Cheng, Kaizhou Jin, Zhiwen Xiao, Guopei Luo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Shengming Deng *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Zhiyao Fan *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Huanyu Xia *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Yitao GongDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Yunzhen QianDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Qiuyi HuangDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
He ChengDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Kaizhou JinDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Zhiwen XiaoDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Guopei LuoDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Xianjun YuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Chen LiuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Shanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe fibrinogen/albumin ratio (FAR) has been widely reported to be a possible biomarker for predicting prognosis in several types of tumors, but the prognostic value of the FAR in pancreatic neuroendocrine neoplasms (Pan-NENs) has not been systematically studied. PATIENTS AND

methodsIn total, 324 patients with Pan-NENs were recruited. The patients were divided into 2 subgroups according to the FAR cutoff value, and clinicopathological characteristics of the 2 subgroups were compared. Overall survival (OS) was the primary endpoint, and progression-free survival (PFS) was the secondary endpoint. The prognostic value of the FAR was analyzed in univariate and multivariate analyses.

resultsThe optimal cutoff value for the FAR was calculated to be 0.08 for OS. The patients with a FAR ≥0.08 had higher proportions of nonfunctioning tumors, Pan-NECs, grade 3 tumors, and stage IV tumors than those with a FAR <0.08. In the univariate analysis, a FAR ≥ 0.08 was associated with poor OS (hazard ratio (HR) = 2.37,

conclusionThe pretreatment FAR, which includes fibrinogen and albumin, was a feasible and predictive biomarker for prognosis in patients with Pan-NENs. An elevated FAR, based on a cutoff value of 0.08, was an independent risk factor for poor OS and PFS.

Indexed as

fibrinogen/albumin ratiopancreatic neuroendocrine neoplasmssurvival

Identifiers

PMID33447083
PMCPMC7802789
OpenAlexW3119492304

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.