ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2020
Prognostic factors affecting long-term outcomes in patients with brain metastasis from esophageal carcinoma.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Incidence and prognosis of brain metastases in esophageal carcinoma: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database.BMC cancer · 2021Article
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4 authors at 2 institutions in 1 country.
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Abstract
objectiveThe incidence of brain metastasis from esophageal cancer (BMEC) has increased in recent years. Thus, it is necessary to identify factors that affect long-term outcomes for such patients.
methodsFrom January 1997 to July 2018, consecutive patients (10,043 patients, 31 with brain metastasis) with esophageal cancer (EC) treated at Zhejiang Cancer Hospital were recruited for retrospective analysis. Demographic, clinical, and pathological variables and the survival data were retrieved.
resultsThe median time from diagnosis of EC to diagnosis of brain metastases was 7.67 (range, 0.43-55.20) months. The median survival time of BMEC patients from diagnosis of primary esophageal tumor was 16.7 (range, 2.33-163.30) months and the median survival time from the point of diagnosis of brain metastasis was 6.47 (range, 0.43-148.13) months. Univariate and multivariate analyses showed that the pathology type, EC without chemotherapy, and bone metastasis history were significantly associated with a shorter time interval between the first treatment of EC and brain metastasis. Chemotherapy history after brain metastasis, whole brain radiation therapy (WBRT) history, and surgery were significant predictors for better long-term survival outcomes.
conclusionsOur findings indicate that the use of surgery, WBRT, and chemotherapy can achieve the best therapeutic effects for BMEC patients.
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