Evidence map›Paper›PMID 33446924›Full record

Trial reportPediatric research2021

Gut priming with bovine colostrum and T regulatory cells in preterm neonates: a randomized controlled trial.

Rania I H Ismail, Hisham A Awad, Safaa S Imam, Ghada I Gad, Nancy M Aboushady, Rania M Abdou, Deena S Eissa, Nesmahar T Azzam, Maha M Barakat, Mostafa M Yassin and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Rania I H IsmailPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hisham A AwadPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Safaa S ImamPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ghada I GadPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Nancy M AboushadyPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Rania M AbdouPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Deena S EissaClinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Nesmahar T AzzamPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Maha M BarakatMinistry of Health, Cairo, Egypt.
Mostafa M YassinMinistry of Health, Cairo, Egypt.
Noha M BarakatPediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. noha.m.barakat@med.asu.edu.eg.
Ain Shams University · EGMinistry of Health and Population · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) and neonatal sepsis are still considered major problems, especially in formula-fed preterm neonates. This study aimed to investigate the effect of bovine colostrum on T regulatory cells, NEC, and late-onset sepsis in preterm neonates ≤34 weeks.

methodsThis prospective double-blind randomized controlled trial was conducted on 80 preterm infants who were randomly assigned to either the bovine colostrum group (n = 32) or control group (n = 48). T lymphocytes and their subsets, necrotizing enterocolitis, late-onset sepsis (LOS) and its severity, feeding tolerance, growth, length of hospital stay, and mortality were documented.

resultsThe bovine colostrum group showed higher follow-up levels of CD4+CD25+ FOXP3+ T lymphocyte % (FOXP3 Tregs). FOXP3 Tregs and its difference in change levels between baseline and follow-up were considered as the most related factors to the bovine colostrum. Bovine colostrum group showed positive trends for reduction of sepsis severity and mortality with no significant difference in the incidence of NEC, LOS, and length of hospital stay.

conclusionsPreterm neonates who received bovine colostrum showed a higher FOXP3 Treg level. IMPACT: Bovine colostrum has no significant effect on the incidence of necrotizing enterocolitis. FOXP3 T regulatory cells and their increased level between baseline and follow-up is considered as the most influencing factors related to the bovine colostrum. Positive trends were noted for reduction of sepsis severity and concomitant mortality, but the study lacked the power to assess these outcomes.

Indexed as

ColostrumInfant, PrematureAnimalsCattleDouble-Blind MethodEnterocolitis, NecrotizingFemaleFlow CytometryHumansIncidenceInfant, NewbornIntestinesMalePregnancyProspective StudiesT-Lymphocytes, Regulatory

Identifiers

PMID33446924
OpenAlexW3119316018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.