ArticlePediatric research2021
Human milk oligosaccharides, infant growth, and adiposity over the first 4 months of lactation.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human Milk Bioactive Components and Child Growth and Body Composition in the First 2 Years: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Influence of infant fucosyltransferase polymorphisms on the association of maternal secretor status with child outcomes: the Ulm birth cohort studies.Scientific reports · 2025Article
- Unaltered 3'-sialyllactose and 6'-sialyllactose concentrations in human milk acutely after endurance exercise: a randomized crossover trial.Frontiers in nutrition · 2025Article
- Role of Human Milk Microbiota in Infant Neurodevelopment: Mechanisms and Clinical Implications.Children (Basel, Switzerland) · 2024Review
- Associations between human milk oligosaccharides and infant growth in a Bangladeshi mother-infant cohort.Pediatric research · 2024Article
- Human milk oligosaccharides and infant growth: a global health approach.Pediatric research · 2024Article
- Patterns of Human Milk Oligosaccharides in Mature Milk Are Associated with Certain Gut Microbiota in Infants.Nutrients · 2024Article
- Human Milk Microbiome and Microbiome-Related Products: Potential Modulators of Infant Growth.Nutrients · 2022Review
- High-Throughput Glycomic Methods.Chemical reviews · 2022Review
- Dynamics of human milk oligosaccharides in early lactation and relation with growth and appetitive traits of Filipino breastfed infants.Scientific reports · 2022Observational
- Biology of human milk oligosaccharides: From basic science to clinical evidence.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Review
- Human Milk Oligosaccharides and Bacterial Profile Modulate Infant Body Composition during Exclusive Breastfeeding.International journal of molecular sciences · 2022Article
- Phylogenetic, Functional and Safety Features of 1950sMicroorganisms · 2022Article
- Use of a Liquid Supplement Containing 2 Human Milk Oligosaccharides: The First Double-Blind, Randomized, Controlled Trial in Pre-term Infants.Frontiers in pediatrics · 2022Article
- Concentrations of oligosaccharides in human milk and child growth.BMC pediatrics · 2021Article
- Article
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between human milk oligosaccharides (HMOs) and infant growth and adiposity is not fully understood and comprehensive studies are missing from the current literature.
methodsWe screened and recruited 370 healthy, pregnant women and their infants from seven European countries. Breastmilk samples were collected using standardized procedures at six time points over 4 months, as were infant parameters. Correlations and associations between HMO area under the curve, anthropometric data, and fat mass at 4 months were tested.
resultsLacto-N-neotetraose had a negative correlation with the change in length (rs = -0.18, P = 0.02). Sialyllacto-N-tetraose c (LSTc) had a positive correlation with weight for length (rs = 0.19, P = 0.015). Infants at the 25th upper percentile were fed milk higher in 3'-sialyllactose and LSTc (P = 0.017 and P = 0.006, respectively) compared to the lower 25th percentile of the weight-for-length z-score gain over 4 months of lactation. No significant associations between growth and body composition and Lewis or secretor-dependent HMOs like 2'-fucosyllactose were identified.
conclusionsChanges in the HMO composition of breastmilk during the first 4 months appear to have little influence on infant growth and body composition in this cohort of healthy mothers and infants. IMPACT: Modest associations exist between individual HMO and infant growth outcomes at least in healthy growing populations. Our study provides a comprehensive investigation of associations between all major HMO and infant growth and adiposity including several time points. Certain groups of HMOs, like the sialylated, may be associated with adiposity during the first months of lactation. HMO may modulate the risk of future metabolic disease. Future population studies need to address the role of specific groups of HMOs in the context of health and disease to understand the long-term impact.
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