Evidence map›Paper›PMID 33446870›Full record

Trial reportScientific reports2021

Improving prognostic performance in resectable pancreatic ductal adenocarcinoma using radiomics and deep learning features fusion in CT images.

Yucheng Zhang, Edrise M Lobo-Mueller, Paul Karanicolas, Steven Gallinger, Masoom A Haider, Farzad Khalvati

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Artificial Intelligence in Pancreatic Imaging: A Systematic Review.United European gastroenterology journal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yucheng ZhangDepartment of Medical Imaging, University of Toronto, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.
Edrise M Lobo-MuellerDepartment of Diagnostic Imaging and Department of Oncology, Faculty of Medicine and Dentistry, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
Paul KaranicolasDepartment of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Masoom A HaiderLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Farzad KhalvatiDepartment of Medical Imaging, University of Toronto, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. Farzad.Khalvati@utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an analytic pipeline for quantitative imaging feature extraction and analysis, radiomics has grown rapidly in the past decade. On the other hand, recent advances in deep learning and transfer learning have shown significant potential in the quantitative medical imaging field, raising the research question of whether deep transfer learning features have predictive information in addition to radiomics features. In this study, using CT images from Pancreatic Ductal Adenocarcinoma (PDAC) patients recruited in two independent hospitals, we discovered most transfer learning features have weak linear relationships with radiomics features, suggesting a potential complementary relationship between these two feature sets. We also tested the prognostic performance for overall survival using four feature fusion and reduction methods for combining radiomics and transfer learning features and compared the results with our proposed risk score-based feature fusion method. It was shown that the risk score-based feature fusion method significantly improves the prognosis performance for predicting overall survival in PDAC patients compared to other traditional feature reduction methods used in previous radiomics studies (40% increase in area under ROC curve (AUC) yielding AUC of 0.84).

Indexed as

Carcinoma, Pancreatic DuctalDeep LearningPancreatic NeoplasmsAdultDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleRetrospective StudiesSurvival RateTomography, X-Ray Computed

Identifiers

PMID33446870
PMCPMC7809062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.