ArticleScientific reports2021
Fungus Metarhizium robertsii and neurotoxic insecticide affect gut immunity and microbiota in Colorado potato beetles.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Synergistic Control ofInsects · 2026Article
- Temperature dependent immunological responses of Spoladea recurvalis exposed to entomopathogenic fungi.Scientific reports · 2026Article
- Intestinal microbiome interactions influence Metarhizium-based biocontrol efficacy against the sugar beet weevil.Scientific reports · 2026Article
- Immunological responses and gut microbial shift of fall armywormFrontiers in microbiology · 2026Article
- The gut microbial community structure of the oriental armyworm Mythimna separata (Walker) (Lepidoptera: Noctuidae) affects the the virulence of the entomopathogenic fungus Metarhizium rileyi.BMC microbiology · 2025Article
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- Pesticide exposure and the microbiota-gut-brain axis.The ISME journal · 2023Review
- Immunological responses and gut microbial shifts inFrontiers in microbiology · 2023Article
- Lipids as a key element of insect defense systems.Frontiers in genetics · 2023Review
- Differential responses of Ceratitis capitata to infection by the entomopathogenic fungus Purpureocillium lilacinum.PloS one · 2023Article
- Expression of Immunity- and Stress-Related Genes during an Intermolt Period in the Colorado Potato Beetle.Insects · 2022Article
- Autoclaved Diet with Inactivated Spores ofAnimals : an open access journal from MDPI · 2022Article
- Topical Fungal Infection Induces Shifts in the Gut Microbiota Structure of Brown Planthopper,Insects · 2022Article
- Identification of the Ricin-B-Lectin LdRBLk in the Colorado Potato Beetle and an Analysis of Its Expression in Response to Fungal Infections.Journal of fungi (Basel, Switzerland) · 2021Article
- Article
- Interplay between Fungal Infection and Bacterial Associates in the Wax MothJournal of fungi (Basel, Switzerland) · 2020Article
- Fungal Endophyte-Mediated Antibiotic and Antixenotic Plant Resistance to Herbivorous Insects.Physiologia plantarumReview
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal infections and toxicoses caused by insecticides may alter microbial communities and immune responses in the insect gut. We investigated the effects of Metarhizium robertsii fungus and avermectins on the midgut physiology of Colorado potato beetle larvae. We analyzed changes in the bacterial community, immunity- and stress-related gene expression, reactive oxygen species (ROS) production, and detoxification enzyme activity in response to topical infection with the M. robertsii fungus, oral administration of avermectins, and a combination of the two treatments. Avermectin treatment led to a reduction in microbiota diversity and an enhancement in the abundance of enterobacteria, and these changes were followed by the downregulation of Stat and Hsp90, upregulation of transcription factors for the Toll and IMD pathways and activation of detoxification enzymes. Fungal infection also led to a decrease in microbiota diversity, although the changes in community structure were not significant, except for the enhancement of Serratia. Fungal infection decreased the production of ROS but did not affect the gene expression of the immune pathways. In the combined treatment, fungal infection inhibited the activation of detoxification enzymes and prevented the downregulation of the JAK-STAT pathway caused by avermectins. The results of this study suggest that fungal infection modulates physiological responses to avermectins and that fungal infection may increase avermectin toxicosis by blocking detoxification enzymes in the gut.
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