ArticleInternational journal of obesity (2005)2021
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.
Article in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- A socio-ecological lens to segmenting adult's eating behaviour.Nutrition and health · 2025Article
- Mediation of genetic susceptibility to obesity through eating behaviours in children.Pediatric obesity · 2025Article
- Beyond BMI: the complex interplay of reward sensitivity, eating behaviors, and BMI in female college students.Frontiers in psychology · 2025Article
- Article
- Exploration of Food Attitudes and Management of Eating Behavior from a Psycho-Nutritional Perspective.Healthcare (Basel, Switzerland) · 2024Article
- Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects.Frontiers in nutrition · 2024Article
- Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Associations of timing of food intake with energy intake, eating behaviour traits and psychosocial factors in adults with overweight and obesity.Frontiers in nutrition · 2023Article
- Role of Leu72Met ofNutrients · 2022Article
- Dietary Mediators of the Genetic Susceptibility to Obesity-Results from the Quebec Family Study.The Journal of nutrition · 2022Article
- Predictors of Post-Exercise Energy Intake in Adolescents Ranging in Weight Status from Overweight to Severe Obesity.Nutrients · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 9 institutions in 5 countries.
Funding
Abstract
BACKGROUND/
objectivesThe mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain. SUBJECTS/
methodsWe followed the body-mass index (BMI) trajectories of 2464 adults from 45 to 65 years of age by measuring weight and height on four occasions at 5-year intervals. Genetic risk of obesity (gene risk score: GRS) was ascertained, comprising 92 BMI-associated single-nucleotide polymorphisms and split at a median (=high and low risk). At the baseline, the Eating Inventory was used to assess appetite-related traits of 'disinhibition', indicative of opportunistic eating or overeating and 'hunger' which is susceptibility to/ability to cope with the sensation of hunger. Roles of the GRS and two appetite-related scores for BMI trajectories were examined using a mixed model adjusted for the cohort effect and sex.
resultsDisinhibition was associated with higher BMI (β = 2.96; 95% CI: 2.66-3.25 kg/m
conclusionsAppetite disinhibition is most likely to be a defining characteristic of genetic susceptibility to obesity. High levels of appetite disinhibition, rather than hunger, may underlie genetic vulnerability to obesogenic environments in two-thirds of the population of European ancestry.
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