Evidence map›Paper›PMID 33446819›Full record

Trial reportScientific reports2021

Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders.

Amanda H Mahnke, Georgios D Sideridis, Nihal A Salem, Alexander M Tseng, R Colin Carter, Neil C Dodge, Aniruddha B Rathod, Christopher D Molteno, Ernesta M Meintjes, Sandra W Jacobson and 2 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Role of ceRNA network in inflammatory cells of rheumatoid arthritis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  15. Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Amanda H Mahnke *Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, 77807, USA. mahnke@tamu.edu.
Georgios D Sideridis *Harvard Medical School, Boston Children's Hospital, Institutional Centers for Clinical and Translational Research, Boston, MA, 02115, USA.
Nihal A Salem *Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, 77807, USA.
Alexander M Tseng *Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, 77807, USA.
R Colin CarterDepartments of Pediatrics and Emergency Medicine, Institute of Human Nutrition, Columbia University Medical Center, New York, NY, 10032, USA.
Neil C DodgeDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Aniruddha B RathodDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, 77807, USA.
Christopher D MoltenoDepartments of Human Biology and of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Ernesta M MeintjesDivision of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Sandra W JacobsonDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Rajesh C MirandaDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, 77807, USA.
Joseph L JacobsonDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA. joseph.jacobson@wayne.edu.
University of Cape Town · ZATexas A&M Health Science Center · USTexas A&M University · USColumbia University Irving Medical Center · USHarvard University · USWayne State University · US

Funding

Prenatal microRNA neuro-therapeutics for fetal alcohol exposureR01AA024659 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MIRANDA, RAJESH C · 2016 to 2020
$1.8M
The Role of Maternal Nutrition in the Teratogenesis of Alcohol in HumansK23AA020516 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CARTER, ROBERT COLIN · 2011 to 2015
$891k
MicroRNAs as Biomarkers of Exposure and Effect in Fetal Alcohol Spectrum DisordersR21AA024055 · NIAAA · WAYNE STATE UNIVERSITY · PI JACOBSON, SANDRA W., MIRANDA, RAJESH C · 2015 to 2016
$508k
Maternal circulating miRNA function in Fetal Alcohol Spectrum DisordersF31AA026505 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI TSENG, ALEXANDER MIKE · 2017 to 2019
$66k
From FASD to AUDs: Strategies for Preventing Alcohol AddictionsF99NS113423 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SALEM, NIHAL A · 2019 to 2019
$34k
NIAAA NIH HHS F31 AA026505NIAAA NIH HHS K23 AA020516NIAAA NIH HHS R01 AA024659NIAAA NIH HHS R21 AA024055NINDS NIH HHS F99 NS113423
6 · The paper itself

Abstract

Prenatal alcohol exposure (PAE) can result in cognitive and behavioral disabilities and growth deficits. Because alcohol-related neurobehavioral deficits may occur in the absence of overt dysmorphic features or growth deficits, there is a need to identify biomarkers of PAE that can predict neurobehavioral impairment. In this study, we assessed infant plasma extracellular, circulating miRNAs (

Indexed as

AdolescentAdultBiomarkersCirculating MicroRNAFemaleFetal Alcohol Spectrum DisordersHumansInfant, NewbornMaleBiomarkersCirculating MicroRNA

Identifiers

PMID33446819
PMCPMC7809131
OpenAlexW3122306375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.