Evidence map›Paper›PMID 33446817›Full record

ArticleScientific reports2021

Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages.

Seegehalli M Anil, Nurit Shalev, Ajjampura C Vinayaka, Stalin Nadarajan, Dvora Namdar, Eduard Belausov, Irit Shoval, Karthik Ananth Mani, Guy Mechrez, Hinanit Koltai

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 135 citations in OpenAlex.

  1. Trial
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  8. New cannabidiol structure-related terpeneFuture medicinal chemistry · 2025
    Article
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  20. Substances of abuse and their effect on SAR-CoV-2 pathogenesis.NeuroImmune pharmacology and therapeutics · 2023
    Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Seegehalli M Anil *Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Nurit Shalev *Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Ajjampura C Vinayaka *Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Stalin Nadarajan *Institute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Dvora NamdarInstitute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Eduard BelausovInstitute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Irit ShovalThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 5290002, Ramat Gan, Israel.
Karthik Ananth ManiInstitute for Postharvest and Food Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Guy MechrezInstitute for Postharvest and Food Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel.
Hinanit KoltaiInstitute of Plant Science, Agriculture Research Organization, Volcani Center, 7528809, Rishon LeZion, Israel. hkoltai@agri.gov.il.
Agricultural Research Organization · ILBar-Ilan University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabis sativa is widely used for medical purposes and has anti-inflammatory activity. This study intended to examine the anti-inflammatory activity of cannabis on immune response markers associated with coronavirus disease 2019 (COVID-19) inflammation. An extract fraction from C. sativa Arbel strain (F

Indexed as

A549 CellsAngiotensin-Converting Enzyme 2Anti-Inflammatory AgentsCannabinoidsCannabisCOVID-19COVID-19 Drug TreatmentCytokinesEpithelial CellsGene Expression RegulationHumansMacrophagesPlant ExtractsReceptors, IgGSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2Anti-Inflammatory AgentsCannabinoidsCytokinesPlant ExtractsReceptors, IgG

Identifiers

PMID33446817
PMCPMC7809280
OpenAlexW3124894221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.