ArticleScientific reports2021
Phasic activation of the locus coeruleus attenuates the acoustic startle response by increasing cortical arousal.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Dopamine D1Aa and D2a Receptor Expression in the Auditory System of a Vocal Fish.The Journal of comparative neurology · 2026Article
- Dopamine D1Aa and D2a Receptor Expression in the Auditory System of a Vocal Fish.bioRxiv : the preprint server for biology · 2025Article
- Article
- Quicker Exogenous Orienting and Slower Endogenous Orienting in Autistic People.Journal of autism and developmental disorders · 2025Article
- REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness.Journal of biomedical science · 2025Article
- Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex.Scientific reports · 2024Article
- The Glutamine Synthetases Are Required for Sensory Hair Cell Formation and Auditory Function in Zebrafish.International journal of molecular sciences · 2024Article
- A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface.Methods and protocols · 2023Article
- Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network.Science advances · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An alerting sound elicits the Acoustic Startle Response (ASR) that is dependent on the sound volume and organisms' state, which is regulated by neuromodulatory centers. The locus coeruleus (LC) neurons respond to salient stimuli and noradrenaline release affects sensory processing, including auditory. The LC hyperactivity is detrimental for sensorimotor gating. We report here that priming microstimulation of the LC (100-ms at 20, 50, and 100 Hz) attenuated the ASR in rats. The ASR reduction scaled with frequency and 100 Hz-stimulation mimicked pre-exposure to a non-startling tone (prepulse). A rapid (~ 40 ms) EEG desynchronization following the LC stimulation suggested that the ASR reduction was due to elevated cortical arousal. The effects of LC stimulation on the ASR and EEG were consistent with systematic relationships between the ASR, awake/sleep state, and the cortical arousal level; for that matter, a lower ASR amplitude corresponded to a higher arousal level. Thus, the LC appears to modulate the ASR circuit via its diffuse ascending projections to the forebrain saliency network. The LC modulation directly in the brainstem and/or spinal cord may also play a role. Our findings suggest the LC as a part of the brain circuitry regulating the ASR, while underlying neurophysiological mechanisms require further investigation.
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