ArticleScientific reports2021
Single-neuron dynamical effects of dendritic pruning implicated in aging and neurodegeneration: towards a measure of neuronal reserve.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
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- Mapping and modeling age-related changes in intrinsic neural timescales.Communications biology · 2025Article
- Estimating the energy of dissipative neural systems.Cognitive neurodynamics · 2024Article
- Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior.Molecular psychiatry · 2024Article
- Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges.Sports (Basel, Switzerland) · 2024Review
- Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.Frontiers in cellular neuroscience · 2024Article
- Brain-wide dendrites in a near-optimal performance of dynamic range and information transmission.Scientific reports · 2023Article
- Injectable Hydrogel Guides Neurons Growth with Specific Directionality.International journal of molecular sciences · 2023Article
- Dysfunction of the neurovascular unit in brain aging.Journal of biomedical research · 2023Article
- Functional Cognitive Disorder Presents High Frequency and Distinct Clinical Profile in Patients With Low Education.Frontiers in aging neuroscience · 2022Article
- Spatially resolved dendritic integration: towards a functional classification of neurons.PeerJ · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is a main risk factor for neurodegenerative disorders including Alzheimer's disease. It is often accompanied by reduced cognitive functions, gray-matter volume, and dendritic integrity. Although age-related brain structural changes have been observed across multiple scales, their functional implications remain largely unknown. Here we simulate the aging effects on neuronal morphology as dendritic pruning and characterize its dynamical implications. Utilizing a detailed computational modeling approach, we simulate the dynamics of digitally reconstructed neurons obtained from Neuromorpho.org. We show that dendritic pruning affects neuronal integrity: firing rate is reduced, causing a reduction in energy consumption, energy efficiency, and dynamic range. Pruned neurons require less energy but their function is often impaired, which can explain the diminished ability to distinguish between similar experiences (pattern separation) in older people. Our measures indicate that the resilience of neuronal dynamics is neuron-specific, heterogeneous, and strongly affected by dendritic topology and the position of the soma. Based on the emergent neuronal dynamics, we propose to classify the effects of dendritic deterioration, and put forward a topological measure of "neuronal reserve" that quantifies the resilience of neuronal dynamics to dendritic pruning. Moreover, our findings suggest that increasing dendritic excitability could partially mitigate the dynamical effects of aging.
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