ArticleScientific reports2021
A new ultradian rhythm in mammalian cell dry mass observed by holography.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Extended Field of View and Resolution Enhancement in Lensless Digital Holography.Sensors (Basel, Switzerland) · 2026Article
- Ultradian and circadian rhythms of phototaxis in chlamydomonas reinhardii.Biochemistry and biophysics reports · 2025Article
- Optimization of experimental designs for biological rhythm discovery.PLoS computational biology · 2025Article
- Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis.eLife · 2025Article
- PI3K Signaling at the Crossroads of Lipid Metabolism and Cancer.Advances in experimental medicine and biology · 2025Review
- Detecting abnormal cell behaviors from dry mass time series.Scientific reports · 2024Article
- Cell size homeostasis is tightly controlled throughout the cell cycle.PLoS biology · 2024Article
- Co-expression of diurnal and ultradian rhythms in the plasma metabolome of common voles (Microtus arvalis).FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Reduced glucose concentration enhances ultradian rhythms inFrontiers in physiology · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have discovered a new 4 h ultradian rhythm that occurs during the interphase of the cell cycle in a wide range of individual mammalian cells, including both primary and transformed cells. The rhythm was detected by holographic lens-free microscopy that follows the histories of the dry mass of thousands of single live cells simultaneously, each at a resolution of five minutes. It was vital that the rhythm was observed in inherently heterogeneous cell populations, thus eliminating synchronization and labeling bias. The rhythm is independent of circadian rhythm, and is temperature-compensated. We show that the amplitude of the fundamental frequency provides a way to quantify the effects of, chemical reagents on cells, thus shedding light on its mechanism. The rhythm is suppressed by proteostasis disruptors and is detected only in proliferating cells, suggesting that it represents a massive degradation and re-synthesis of protein every 4 h in growing cells.
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