ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Premotor Ramping of Thalamic Neuronal Activity Is Modulated by Nigral Inputs and Contributes to Control the Timing of Action Release.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Hierarchically and Temporally Distinct CaCNS neuroscience & therapeutics · 2026Article
- Brain-Wide Activations Related to Forepaw Force Control Identified by Behaving Mouse FMRI.eNeuro · 2026Article
- A brain-wide, trial- and time-dependent deterministic drive synergizes with within-trial noise to time self-initiated actions.bioRxiv : the preprint server for biology · 2026Article
- Medullary and C3-C4 propriospinal pathways underlying mammalian forelimb movement control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Selective coupling and decoupling coordinate distributed brain networks for precise action.bioRxiv : the preprint server for biology · 2025Article
- Article
- Movement-related activity in the internal globus pallidus of the parkinsonian macaque.Journal of neurophysiology · 2025Article
- Transdiagnostic neuromodulation of impulsivity: current status and future trajectories.Translational psychiatry · 2025Review
- Article
- Parkinsonism Disrupts Neuronal Modulation in the Presupplementary Motor Area during Movement Preparation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Preconfigured cortico-thalamic neural dynamics constrain movement-associated thalamic activity.Nature communications · 2024Article
- The Interactions of Temporal and Sensory Representations in the Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Article
- Article
- Cerebellar and basal ganglia inputs define three main nuclei in the mouse ventral motor thalamus.Frontiers in neuroanatomy · 2023Article
- Micropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs.Frontiers in neuroanatomy · 2023Article
- Neural basis of anticipation and premature impulsive action in the frontal cortex.Nature neuroscience · 2022Article
- Thalamus-driven functional populations in frontal cortex support decision-making.Nature neuroscience · 2022Article
- Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.Cell reports · 2022Article
- Thalamic input to motor cortex facilitates goal-directed action initiation.Current biology : CB · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The ventromedial (VM)/ventro-anterior-lateral (VAL) motor thalamus is a key junction within the brain circuits sustaining normal and pathologic motor control functions and decision-making. In this area of thalamus, on one hand, the inhibitory nigro-thalamic pathway provides a main output from the basal ganglia, and, on the other hand, motor thalamo-cortical loops are involved in the maintenance of ramping preparatory activity before goal-directed movements. To better understand the nigral impact on thalamic activity, we recorded electrophysiological responses from VM/VAL neurons while male and female mice were performing a delayed right/left decision licking task. Analysis of correct (corr) and error trials revealed that thalamic ramping activity was stronger for premature licks (impulsive action) and weaker for trials with no licks [omission (omi)] compared with correct trials. Suppressing ramping activity through optogenetic activation of nigral terminals in the motor thalamus during the delay epoch of the task led to a reduced probability of impulsive action and an increased amount of omissions trials. We propose a parsimonious model explaining our data and conclude that a thalamic ramping mechanism contributes to the control of proper timing of action release and that inhibitory nigral inputs are sufficient to interrupt this mechanism and modulate the amount of motor impulsivity in this task.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.