Evidence map›Paper›PMID 33446493›Full record

ArticleImmunoHorizons2021

STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses.

Adam J Fike, Sathi Babu Chodisetti, Kristen N Bricker, Nicholas M Choi, Zissis C Chroneos, Mark H Kaplan, Ziaur S M Rahman

Open access · goldAbstract read
In one paragraph

Article in ImmunoHorizons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Regulation of B Cell Responses in SLE by Three Classes of Interferons.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adam J FikeDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033.
Sathi Babu ChodisettiDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033.
Kristen N BrickerDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033.ORCID 0000-0001-8963-9780
Nicholas M ChoiDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033.
Zissis C ChroneosDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033.
Mark H KaplanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.
Ziaur S M RahmanDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033; zrahman@pennstatehealth.psu.edu.ORCID 0000-0001-8431-9681
Pennsylvania State University · USIndiana University – Purdue University Indianapolis · US

Funding

IRF7-mediated development of autoreactive B cells and SLER01AI162971 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI RAHMAN, ZIAUR · 2021 to 2025
$2.7M
Role of miRNAs in toll-like receptor-mediated autoimmune B cell response and lupus-like autoimmunityR21AI128111 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI RAHMAN, ZIAUR · 2017 to 2018
$421k
NIAID NIH HHS R01 AI162971NIAID NIH HHS R21 AI128111
6 · The paper itself

Abstract

Genome-wide association studies identified variants in the transcription factor

Indexed as

AnimalsAutoantibodiesAutoantigensAutoimmunityB-LymphocytesDisease Models, AnimalGenome-Wide Association StudyGerminal CenterLupus Erythematosus, SystemicMiceMice, Inbred C57BLSTAT4 Transcription FactorT-Lymphocytes, Helper-InducerAutoantibodiesAutoantigensStat4 protein, mouseSTAT4 Transcription Factor

Identifiers

PMID33446493
PMCPMC12090115
OpenAlexW3120927548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.