ArticleProceedings of the National Academy of Sciences of the United States of America2021
On the utility of CSF1R inhibitors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties.Neuron · 2026Article
- Contrasting contribution of resident and repopulated brain macrophages in sustaining sleep-wake circuitry.Communications biology · 2025Article
- Evaluating the Optic Nerve Crush Model to Understand the Function of Microglia in Glaucoma Neuroprotection.Investigative ophthalmology & visual science · 2025Article
- Long-term reprogramming of primed microglia after moderate inhibition of CSF1R signaling.Glia · 2025Article
- Novel microglial transcriptional signatures promote social and cognitive deficits following repeated social defeat.Communications biology · 2024Article
- Transcriptional and epigenetic decoding of the microglial aging process.Nature aging · 2023Article
- Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection.Acta neuropathologica communications · 2023Article
- Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain.Neuroscience bulletin · 2023Review
- Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation.Frontiers in immunology · 2023Article
- Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome.Glia · 2022Article
- Microglia maintain the normal structure and function of the hippocampal astrocyte network.Glia · 2022Article
- Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.Acta neuropathologica · 2022Review
- What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior.Frontiers in cellular neuroscience · 2022Review
- PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production.Frontiers in immunology · 2022Article
- Microglia Reduce Herpes Simplex Virus 1 Lethality of Mice with Decreased T Cell and Interferon Responses in Brains.International journal of molecular sciences · 2021Article
- Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders.Frontiers in aging neuroscience · 2021Review
- Glial Cells Promote Myelin Formation and Elimination.Frontiers in cell and developmental biology · 2021Review
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Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.