Evidence map›Paper›PMID 33446414›Full record

ReviewAnnales de pathologie2021

[Histopathological features due to the SARS-CoV-2].

Paul Hofman, Marie-Christine Copin, Arnault Tauziede-Espariat, Homa Adle-Biassette, Francesco Fortarezza, Thierry Passeron, Isabelle Salmon, Fiorella Calabrese

Abstract readReview
In one paragraph

Review in Annales de pathologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Determinants of abnormal liver-related biomarkers in adult COVID-19 patients.Frontiers in cellular and infection microbiology · 2025
    Article
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul HofmanLaboratoire de pathologie clinique et expérimentale, hôpital Pasteur, centre hospitalo-universitaire de Nice, université Côte d'Azur, B.P. 69-30, avenue de la voie romaine, 06001 Nice cedex 01, France; Biobanque hospitalière (BB-0033-00025), hôpital Pasteur, Nice, France; FHU OncoAge, hôpital Pasteur, Nice, France. Electronic address: hofman.p@chu-nice.fr.
Marie-Christine CopinUniversité d'Angers, Inserm, CRCINA, Angers, France; Département de pathologie, centre hospitalo-universitaire, Angers, France.
Arnault Tauziede-EspariatService de neuropathologie, GHU de Paris psychiatrie et neurosciences, hôpital Saint-Anne, Paris, France.
Homa Adle-BiassetteService de pathologie, hôpital Lariboisière, AP-HP, Paris, France.
Francesco FortarezzaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Padova, Italie.
Thierry PasseronDépartement de dermatologie, hôpital Archet II, centre hospitalo-universitaire de nice, université Côte d'Azur, Nice, France.
Isabelle SalmonDépartement de pathologie, hôpital Erasme, université Libre de Bruxelles, Bruxelles, Belgique.
Fiorella CalabreseDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Padova, Italie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The infection due to the SARS-CoV-2 leads lesions mainly observed at the respiratory tract level, but not exclusively. The analyses of these lesions benefited from different autopsy studies. Thus, these lesions were observed in different organs, tissues and cells. These observations allowed us to rapidly improve the knowledge of the pathophysiological mechanisms associated with this emergent infectious disease. The virus can be detected in formalin fixed paraffin embedded tissues using immunohistochemistry, in situ hybridization, molecular biology and/or electron microscopy approaches. However, many uncertainties are still present concerning the direct role of the SARS-CoV-2 on the different lesions observed in different organs, outside the lung, such as the heart, the brain, the liver, the gastrointestinal tract, the kidney and the skin. In this context, it is pivotal to keep going to increase the different tissue and cellular studies in the COVID-19 positive patients aiming to better understanding the consequences of this new infectious disease, notably considering different epidemiological and co-morbidities associated factors. This could participate to the development of new therapeutic strategies too. The purpose of this review is to describe the main histological and cellular lesions associated with the infection due to the SARS-CoV-2.

Indexed as

AutopsyCOVID-19FibrosisHistocytochemistryHumansImmunohistochemistryIn Situ HybridizationKidneyLiverLungSARS-CoV-2SkinThrombosisAncillary toolsAutopsieAutopsyCOVID-19Études ancillairesPathologiePathologyPathophysiologyPhysiopathologie

Identifiers

PMID33446414
PMCPMC7773006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.