ArticleChinese neurosurgical journal2021
Multifocal glioblastoma-two case reports and literature review.
Article in Chinese neurosurgical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Case Report: Rare presentations of glioblastoma: three multifocal and one cerebellar cases highlighting the value of shared clinical experience.Frontiers in oncology · 2026Article
- Article
- Glioma mimicking a cystic infectious disease: A case report of multifocal, multicentric cystic glioblastoma.Surgical neurology international · 2025Article
- Multiple Glioblastomas Ablation by Laser Interstitial Thermal Therapy (LITT): A Rare Case.Cureus · 2024Article
- Poly (β-amino Ester) Nanoparticles Modified with a Rabies Virus-derived peptide for the Delivery ofACS applied nano materials · 2023Article
- Transtentorial spread of glioblastoma multiforme to cerebellopontine angle - A rare case report.Surgical neurology international · 2022Article
- Catalase Overexpression Drives an Aggressive Phenotype in Glioblastoma.Antioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundMultifocal glioblastoma is a rare type of glioblastoma with worse prognosis. In this article, we aimed to report two cases of classical multifocal glioblastoma. CASE PRESENTATION: In case 1, a 47-year-old male presented with dizziness, and once had a sudden loss of consciousness accompanied by convulsion of limbs. Contrast-enhanced MRI showed multiple lesions with heterogeneously ring-enhanced characters in the left hemisphere, diagnosed as multifocal glioblastoma. He underwent a craniotomy of all lesions, concurrent radiotherapy and chemotherapy as well as additional chemotherapy of temozolomide. After 2 cycles, repeat MRI showed that the new lesions already occurred and progressed. Eventually, he abandoned the chemotherapy after the 2 cycles and died 1 year later. In case 2, a 71-year-old male presented with a history of headache, left limb weakness, and numbness. Discontinuous convulsion of limbs once occurred. Contrast-enhanced MRI showed multiple lesions located in the right hemisphere, diagnosed as multifocal glioblastoma. He underwent a right frontoparietal craniotomy of the main lesion. Hemorrhage of the residual tumor and pulmonary artery embolism occurred synchronously. Eventually, his family decided not to pursue any further treatment and opted for hospice care and he passed away within 11 days of surgery.
conclusionsWe reported two cases of typical multifocal glioblastoma. Valid diagnosis is crucial; then, resection of multiple lesions and canonical radio-chemotherapy probably bring survival benefits.
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