Evidence map›Paper›PMID 33446267›Full record

ArticleInternational journal of retina and vitreous2021

Epiretinal membrane surgery outcome in eyes with abnormalities of the central bouquet.

Max P Brinkmann, Stephan Michels, Carolin Brinkmann, Felix Rommel, Mahdy Ranjbar, Nicole Graf Johansen, Matthias Becker

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In one paragraph

Article in International journal of retina and vitreous, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Max P BrinkmannDepartment of Ophthalmology, Stadtspital Waid und Triemli Zürich, Zurich, Switzerland. max.p.brinkmann@gmail.com.
Stephan MichelsDepartment of Ophthalmology, University of Zürich, Zurich, Switzerland.
Carolin BrinkmannLaboratory for Angiogenesis & Ocular Cell Transplantation, University of Lübeck, Lübeck, Germany.
Felix RommelLaboratory for Angiogenesis & Ocular Cell Transplantation, University of Lübeck, Lübeck, Germany.
Mahdy RanjbarLaboratory for Angiogenesis & Ocular Cell Transplantation, University of Lübeck, Lübeck, Germany.
Nicole Graf JohansenGraf Biostatistics, Winterthur, Switzerland.
Matthias BeckerDepartment of Ophthalmology, Stadtspital Waid und Triemli Zürich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical studies have shown that epiretinal membranes (ERM) as well as abnormalities of the central foveal bouquet (CB) can be classified in different stages according to their morphological appearance. Furthermore, visual acuity correlates with the different stages of these features. The present study evaluated how these findings change after the surgical removal of the ERM and their impact on functional outcomes.

methodsIn this retrospective study eyes with ERM were evaluated by SD-OCT scans before and after pars plana vitrectomy (PPV) with macular ERM and internal limiting membrane (ILM) peeling. CB abnormalities were classified according to their morphological appearance from stage 0 (no abnormalities) to stage 3 (acquired vitelliform lesion). ERMs were classified ranging from stage 0 (absence of ERM) to stage 4 (ERM with significant anatomic disruption of macula). Changes in morphology were correlated with visual acuity before and after surgery.

results151 eyes were included into the study. Before surgery 27.2% (n = 41) of eyes showed CB abnormalities with stage 1 being the most common (11.9%, n = 18). Before surgery ERM was seen in all patients. The most common form was stage 1 (28.5%, n = 43), followed by stage 3 (27.8%, n = 42) and 2 (25.2%, n = 38). Only 18.5% (n = 28) presented with stage 4 ERM. The mean BCVA was 0.42 (logMAR) before and increased to 0.19 (logMAR) 8 weeks after vitrectomy (95% CI 0.20-0.28; p < 0.001). Patients who suffered from CB abnormalities had less increase in BCVA than patients who had no evidence of CB (0.28 vs. 0.14 logMAR; p < 0.001). Of all the patients with CB abnormalities at baseline, 68% had lower CB grading after the surgery (n = 28; 95% CI; p < 0.001). All patients showed an improvement of their ERM grading, with 98.7% reaching stage 0 (n = 151 vs. n = 149; 95% CI; p < 0.001).

conclusionsThe study indicates that the presence of CB abnormalities correlates with worse visual function. They are furthermore associated with worse visual outcomes after PPV with ERM and ILM peeling. These findings are valuable for deciding on PPV in patients with ERM.

Indexed as

Acquired vitelliform lesionEpiretinal membraneFoveal bouquetMembrane peelingPredictive factorVitrectomy

Identifiers

PMID33446267
PMCPMC7809764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.