ArticleItalian journal of pediatrics2021
Morbidity associated with patent ductus arteriosus in preterm newborns: a retrospective case-control study.
Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- The association between patent ductus arteriosus and adverse outcomes in preterm infants.BMC pediatrics · 2026Article
- Clinical Impact of the PDA and Its Management on Outcomes of Preterm Infants with NEC: A Review.American journal of perinatology · 2026Review
- Factors influencing diagnostic discrepancy between preoperative transthoracic echocardiography and cardiovascular angiography in patent ductus arteriosus intervention: a multicenter retrospective study.Frontiers in pediatrics · 2026Article
- Review
- Correlation analysis between patent ductus arteriosus and bronchopulmonary dysplasia in premature infants.Italian journal of pediatrics · 2025Article
- A predictive model for prognosis in infants with surgical necrotizing enterocolitis.Italian journal of pediatrics · 2025Article
- Article
- Electrical cardiometry for early detection of hemodynamically significant patent ductus arteriosus in preterm infants.Journal of Taibah University Medical Sciences · 2025Article
- Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System.Paediatric drugs · 2024Article
- Morbidity and neurodevelopmental outcomes at 2 years in preterm infants undergoing percutaneous transcatheter closure vs. surgical ligation of the PDA.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Outcomes of postnatal systemic corticosteroids administration in ventilated preterm newborns: a systematic review of randomized controlled trials.Frontiers in pediatrics · 2024Review
- Early Energy Intake and Amino Acid Profile in Preterm Newborns: A Quasi-Experimental Study.Nutrients · 2023Article
- Oxygen for the Newborn: Friend or Foe?Children (Basel, Switzerland) · 2023Review
- Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants.International journal of molecular sciences · 2023Review
- Article
- Complementary Feeding and Growth in Infants Born Preterm: A 12 Months Follow-Up Study.Children (Basel, Switzerland) · 2021Article
- Early Enteral Feeding Improves Tolerance of Parenteral Nutrition in Preterm Newborns.Nutrients · 2021Observational
- Neonatal Hyperglycemia Related to Parenteral Nutrition Affects Long-Term Neurodevelopment in Preterm Newborn: A Prospective Cohort Study.Nutrients · 2021Article
- Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study.Nutrients · 2021Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAssociation between persistency of a patent ductus arteriosus (PDA) and morbidity in preterm newborns is still controversial. We aimed to investigate the relation between PDA and morbidity in a large retrospective study.
methodsA case-control study including neonates consecutively admitted to the Neonatal Intensive Care Unit (NICU), with gestational age (GA) < 32 weeks or body birth weight (BW) < 1500 g, over a 5-year period. Newborns were divided into Cases and Controls, according with the presence or absence of a hemodynamically significant PDA (hs-PDA).
resultsWe enrolled 85 Cases and 193 Controls. Subjects with hs-PDA had significantly (p < 0.001) lower GA (26.7 w, 95%CI 27.1-28.0 vs. 30.1 w, 95%CI 29.7-30.4), BW (1024 g, 95% CI 952-1097 vs. 1310 g 95%CI 1263-1358) and an increased morbidity (60.0% vs. 18.7%). In a sub-group of extremely preterm newborns (GA ≤ 28 weeks and BW ≤ 1000 g), the rate of bronchopulmonary dysplasia (BPD) was significantly increased in Cases (31.7%) compared with Controls (5.9%, p = 0.033). Multivariate analysis showed that morbidity significantly depended on hs-PDA, GA and BW, and that, in extremely preterms, the hs-PDA represented an independent risk factor for BPD.
conclusionsOccurrence of the main morbidities of prematurity depended by hs-PDA, in association with GA, BW, and use of prenatal steroids. In extremely premature babies, hs-PDA is a risk factor for BPD, one of the most important morbidity of prematurity, independently by other confounding variables.
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