Evidence map›Paper›PMID 33446178›Full record

ArticleBMC complementary medicine and therapies2021

Fermentation of Panax notoginseng root extract polysaccharides attenuates oxidative stress and promotes type I procollagen synthesis in human dermal fibroblast cells.

Shiquan You, Xiuqin Shi, Dan Yu, Dan Zhao, Quan An, Dongdong Wang, Jiachan Zhang, Meng Li, Changtao Wang

Abstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. EGF-loaded, bioactive-richFrontiers in cell and developmental biology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Effect ofFoods (Basel, Switzerland) · 2025
    Article
  7. Protective Effect ofClinical, cosmetic and investigational dermatology · 2024
    Article
  8. Review
  9. Review
  10. FermentedFood science & nutrition · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Exploring the Protective and Reparative Mechanisms ofClinical, cosmetic and investigational dermatology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shiquan You *Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China.
Xiuqin Shi *Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China.
Dan YuBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China.
Dan ZhaoBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China.
Quan AnYunnan Baiyao Group Co., Ltd, Kunming, 650000, China.
Dongdong WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China.
Jiachan ZhangBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China.
Meng LiBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China. limeng@btbu.edu.cn.ORCID http://orcid.org/0000-0002-7354-6480
Changtao WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Fucheng Road, Beijing, 100048, China. wangct@th.btbu.edu.cn.

Funding

Applied Basic Research Key Project of Yunnan 2018ZF005
6 · The paper itself

Abstract

backgroundPanax notoginseng is one of the most valuable traditional Chinese medicines. Polysaccharides in P. notoginseng has been shown to significantly reduce the incidence of human diseases. However the application of fermentation technology in Panax notoginseng is not common, and the mechanism of action of P. notoginseng polysaccharides produced by fermentation is still unclear. The specific biological mechanisms of fermented P. notoginseng polysaccharides (FPNP) suppresses H

methodsIn this study, the effects of water extracted and fermentation on concentration of polysaccharides in P. notoginseng extracts were analyzed. After the H

resultsThe polysaccharide content of Panax notoginseng increased after Saccharomyces cerevisiae CGMCC 17452 fermentation. In the FPNP treatment group, ROS and MDA contents were decreased, reversed the down-regulation of the antioxidant activity and expression of antioxidant enzyme (CAT, GSH-Px and SOD) induced by H

conclusionIt was shown that FPNP could inhibit the damage of collagen and elastin induced by H

Indexed as

Cells, CulturedCollagen Type IDermisFermentationFibroblastsHumansHydrogen PeroxideOxidative StressPanax notoginsengPlant ExtractsPlant RootsPolysaccharidesSignal TransductionSmad ProteinsTransforming Growth Factor betaCollagen Type IHydrogen PeroxidePlant ExtractsPolysaccharidesSmad ProteinsTransforming Growth Factor betaFermentationOxidative stressPanax notoginsengPolysaccharidesTGF-β/Smad signaling pathway

Identifiers

PMID33446178
PMCPMC7807718

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.