Evidence map›Paper›PMID 33446135›Full record

Observational studyBMC nephrology2021

Determinants of mortality in a large group of hemodialysis patients hospitalized for COVID-19.

Kenan Turgutalp, Savas Ozturk, Mustafa Arici, Necmi Eren, Numan Gorgulu, Mahmut Islam, Sami Uzun, Tamer Sakaci, Zeki Aydin, Erkan Sengul and 17 more

Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  12. Clinical manifestations of COVID-19 infection in dialysis patients and protective effect of COVID-19 vaccine.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
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  18. [Treatment of patients with COVID-19 on Hemodialysis: Efficacy of Remdesivir].Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 1 country.

Kenan TurgutalpDepartment of Nephrology, Mersin University Faculty of Medicine, Mersin, Turkey.
Savas OzturkDepartment of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
Mustafa AriciDepartment of Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey. marici@hacettepe.edu.tr.
Necmi ErenDepartment of Nephrology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Numan GorguluDepartment of Internal Medicine, Division of Nephrology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey.
Mahmut IslamDepartment of Nephrology, Zonguldak Ataturk State Hospital, Zonguldak, Turkey.
Sami UzunDepartment of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
Tamer SakaciHealth Sciences University, Sisli Hamidiye Etfal Education and Research Hospital, Nephrology Department, Istanbul, Turkey.
Zeki AydinDepartment of Nephrology, Darica Farabi Training and Research Hospital, Kocaeli, Turkey.
Erkan SengulHealth Science University, Kocaeli Derince Education and Research Hospital, Division of Nephrology, Kocaeli, Turkey.
Bulent DemirelliDepartment of Nephrology, University of Health Sciences, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
Yavuz AyarDepartment of Nephrology, Bursa City Hospital, Bursa, Turkey.
Mehmet Riza AltiparmakDepartment of Internal Medicine, Division of Nephrology, Istanbul University- Cerrahpasa Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Savas SipahiDepartment of Internal Medicine, Division of Nephrology, Sakarya University Faculty of Medicine, Education and Research Hospital, Sakarya, Turkey.
Ilay Berke MentesDepartment of Internal Medicine, Division of Nephrology, Marmara University School of Medicine. Marmara University Pendik Education and Research Hospital, Istanbul, Turkey.
Tuba Elif OzlerDepartment of Internal Medicine, Division of Nephrology, Kanuni Sultan Suleyman Research and Training Hospital, Istanbul, Turkey.
Ebru Gok OguzDepartment of Nephrology, University of Health Sciences, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Bulent HuddamDepartmant of Internal Medicine, Division of Nefrology, Mugla Sitki Kocman University Faculty of Medicine, Education and Research Hospital, Mugla, Turkey.
Ender HurDepartment of Nephrology, Manisa Merkezefendi State Hospital, Manisa, Turkey.
Rumeyza KazanciogluDepartment of Internal Medicine, Division of Nephrology, Bezmialem Vakif University, Istanbul, Turkey.
Ozkan GungorDepartment of Nephrology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.
Bulent TokgozErciyes University School of Medicine Department of Nephrology, Kayseri, Turkey.
Halil Zeki TonbulDepartment of Internal Medicine, Division of Nephrology, Necmettin Erbakan University, Konya, Turkey.
Alaattin YildizDepartment of Internal Medicine, Division of Nephrology, Istanbul University, Istanbul School of Medicine, Istanbul, Turkey.
Siren SezerDepartment of Internal Medicine and Nephrology, Atılım University Faculty of Medicine, Ankara, Turkey.
Ali Riza OdabasDepartment of Nephrology, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
Kenan AtesAnkara University Faculty of Medicine Department of Nephrology, Ankara, Turkey.
Sağlık Bilimleri Üniversitesi · TRHaseki Eğitim ve Araştırma Hastanesi · TRAnkara University · TRAtilim University · TRBezmiâlem Vakıf Üniversitesi · TRBülent Ecevit University · TRBursa Technical University · TRErciyes University · TRFarabi Hastanesi · TRHacettepe University · TRİstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi · TRIstanbul University · TRIstanbul University-Cerrahpaşa · TRKahramanmaraş Sütçü İmam University · TRKocaeli Üniversitesi · TRMarmara University · TRMersin Üniversitesi · TRMuğla University · TRNecmettin Erbakan University · TRSakarya University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinants of mortality in a large group of MHD patients hospitalized for COVID-19.

methodsThis multicenter, retrospective, observational study collected data from 47 nephrology clinics in Turkey. Baseline clinical, laboratory and radiological characteristics, and COVID-19 treatments during hospitalization, need for intensive care and mechanical ventilation were recorded. The main study outcome was in-hospital mortality and the determinants were analyzed by Cox regression survival analysis.

resultsOf 567 MHD patients, 93 (16.3%) patients died, 134 (23.6%) patients admitted to intensive care unit (ICU) and 91 of the ones in ICU (67.9%) needed mechanical ventilation. Patients who died were older (median age, 66 [57-74] vs. 63 [52-71] years, p = 0.019), had more congestive heart failure (34.9% versus 20.7%, p = 0.004) and chronic obstructive pulmonary disease (23.6% versus 12.7%, p = 0.008) compared to the discharged patients. Most patients (89.6%) had radiological manifestations compatible with COVID-19 pulmonary involvement. Median platelet (166 × 10

conclusionHospitalized MHD patients with COVID-19 had a high mortality rate. Older age, presence of heart failure, clinical severity of the disease at presentation, ferritin level on admission, decrease in platelet count and increase in AST level during hospitalization may be used to predict the mortality risk of these patients.

Indexed as

Renal DialysisAgedCOVID-19Critical CareFemaleHeart FailureHospitalizationHospital MortalityHumansKidney Failure, ChronicMaleMiddle AgedPandemicsPulmonary Disease, Chronic ObstructiveRadiographyRespiration, ArtificialClinical findingsCOVID-19HemodialysisMortalityRadiological manifestations

Identifiers

PMID33446135
PMCPMC7808398
OpenAlexW3125638506

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.