ArticleInternational journal of stroke : official journal of the International Stroke Society2021
Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial.
Article in International journal of stroke : official journal of the International Stroke Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03181360 (Tenecteplase in Wake-up Ischaemic Stroke Trial), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST). A Randomised-controlled Trial of Thrombolytic Treatment With Tenecteplase for Acute Ischaemic Stroke Upon Awakening
Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST).Trials · 2022Trial
- Workload and clinical impact of MRI-based extension of reperfusion therapy time window in acute ischaemic stroke-a prospective single-centre study.GeroScience · 2025Article
- Up-to-date advance in the relationship between OSA and stroke: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Intravenous Tenecteplase for Acute Ischemic Stroke Within 4.5-24 Hours of Onset (ROSE-TNK): A Phase 2, Randomized, Multicenter Study.Journal of stroke · 2023Article
- Big Data in Stroke: How to Use Big Data to Make the Next Management Decision.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke.European stroke journal · 2023Article
- Replacing Alteplase with Tenecteplase: Is the Time Ripe?Journal of stroke · 2023Review
- Article
- Is tenecteplase ready to replace alteplase to treat acute ischaemic stroke? The knowns and unknowns.Stroke and vascular neurology · 2022Article
- Tenecteplase or Alteplase: What Is the Thrombolytic Agent of the Future?Current treatment options in neurology · 2022Review
- Intravenous thrombolysis in ischemic stroke patients based on non-contrast CT in the extended time-window.Frontiers in stroke · 2022Review
- Application of Multimodal Magnetic Resonance Imaging in Green Channel of Acute and Hyperacute Ischemic Stroke.Contrast media & molecular imaging · 2022Article
Corrections and comments
- Erratum issuedCorrigendum.2021
Authors and funding
19 authors at 13 institutions in 8 countries.
Funding
Abstract
backgroundPatients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment, but studies indicate that treatment based on non-contrast CT criteria may be safe. Tenecteplase has shown promising results in patients with acute ischemic stroke. The aim of the Tenecteplase in Wake-up Ischemic Stroke Trial (TWIST) is to compare the effect of thrombolytic treatment with tenecteplase and standard care versus standard care alone in patients with wake-up ischemic stroke selected by non-contrast CT. METHODS/
designTWIST is an international, investigator-initiated, multi-centre, prospective, randomized-controlled, open-label, blinded end-point trial of tenecteplase ( DISCUSSION: TWIST aims to determine the effect and safety of thrombolytic treatment with tenecteplase in patients with wake-up ischemic stroke selected by non-contrast CT.
trial registrationClinicalTrials.gov NCT03181360. EudraCT Number 2014-000096-80.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.