Evidence map›Paper›PMID 33446061›Full record

ReviewTissue engineering. Part B, Reviews2022

Bioreactors for Vocal Fold Tissue Engineering.

Ana M Gracioso Martins, Andreea Biehl, Daphne Sze, Donald O Freytes

Open access · greenAbstract readReview
In one paragraph

Review in Tissue engineering. Part B, Reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ana M Gracioso MartinsJoint Department of Biomedical Engineering, College of Engineering, North Carolina State University/University of North Carolina-Chapel Hill, Raleigh, North Carolina, USA.
Andreea BiehlJoint Department of Biomedical Engineering, College of Engineering, North Carolina State University/University of North Carolina-Chapel Hill, Raleigh, North Carolina, USA.
Daphne SzeJoint Department of Biomedical Engineering, College of Engineering, North Carolina State University/University of North Carolina-Chapel Hill, Raleigh, North Carolina, USA.
Donald O FreytesJoint Department of Biomedical Engineering, College of Engineering, North Carolina State University/University of North Carolina-Chapel Hill, Raleigh, North Carolina, USA.
North Carolina State University · US

Funding

Optimal Tissue Engineering Approach for Treating Injured Vocal FoldsR01DC017139 · NIDCD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI FREYTES, DONALD O · 2019 to 2023
$2.7M
Augmenting Vocal Fold Repair Using an Optimized Lamina Propria Extracellular Matrix Derived HydrogelR01DC017743 · NIDCD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI FREYTES, DONALD O · 2019 to 2023
$2.7M
Training Grant in Comparative Molecular MedicineT32GM133393 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Matthew B Fisher, Caroline Laplante · 2021 to 2026
$1.7M
NIDCD NIH HHS R01 DC017139NIDCD NIH HHS R01 DC017743NIGMS NIH HHS T32 GM133393
6 · The paper itself

Abstract

It is estimated that almost one-third of the United States population will be affected by a vocal fold (VF) disorder during their lifespan. Promising therapies to treat VF injury and scarring are mostly centered on VF tissue engineering strategies such as the injection of engineered biomaterials and cell therapy. VF tissue engineering, however, is a challenging field as the biomechanical properties, structure, and composition of the VF tissue change upon exposure to mechanical stimulation. As a result, the development of long-term VF treatment strategies relies on the characterization of engineered tissues under a controlled mechanical environment. In this review, we highlight the importance of bioreactors as a powerful tool for VF tissue engineering with a focus on the current state of the art of bioreactors designed to mimic phonation

Indexed as

Tissue EngineeringVocal CordsBiocompatible MaterialsBioreactorsCicatrixHumansBiocompatible Materialsbioreactorfibrosisgene expressioninflammationlamina propriavocal fold

Identifiers

PMID33446061
PMCPMC8892964
OpenAlexW3124986078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.