Evidence map›Paper›PMID 33445998›Full record

ArticleInnate immunity2021

Existence of natural mouse IgG mAbs recognising epitopes shared by malondialdehyde acetaldehyde adducts and

Mikael Kyrklund, Heidi Kaski, Ramin Akhi, Antti E Nissinen, Outi Kummu, Ulrich Bergmann, Pirkko Pussinen, Sohvi Hörkkö, Chunguang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mikael KyrklundMedical Microbiology and Immunology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Finland.
Heidi KaskiMedical Microbiology and Immunology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Finland.ORCID 0000-0003-2109-9356
Ramin AkhiMedical Microbiology and Immunology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Finland.
Antti E NissinenMedical Microbiology and Immunology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Finland.
Outi KummuMedical Microbiology and Immunology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Finland.
Ulrich BergmannProtein Analysis Core Facility, Biocentre Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland.
Pirkko PussinenOral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Finland.ORCID 0000-0003-3563-1876
Sohvi HörkköMedical Microbiology and Immunology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Finland.
Chunguang WangMedical Microbiology and Immunology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, Finland.ORCID 0000-0001-5569-321X
Oulu University Hospital · FIUniversity of Oulu · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural Abs are produced by B lymphocytes in the absence of external Ag stimulation. They recognise self, altered self and foreign Ags, comprising an important first-line defence against invading pathogens and serving as innate recognition receptors for tissue homeostasis. Natural IgG Abs have been found in newborns and uninfected individuals. Yet, their physiological role remains unclear. Previously, no natural IgG Abs to oxidation-specific epitopes have been reported. Here, we show the cloning and characterisation of mouse IgG mAbs against malondialdehyde acetaldehyde (MAA)-modified low-density lipoprotein. Sequence analysis reveals high homology with germline genes, suggesting that they are natural. Further investigation shows that the MAA-specific natural IgG Abs cross-react with the major periodontal pathogen

Indexed as

AcetaldehydeAnimalsAntibodies, MonoclonalClone CellsEpitopes, B-LymphocyteFimbriae ProteinsGingipain Cysteine EndopeptidasesImmunity, InnateImmunoglobulin GLipoproteins, LDLMalondialdehydeMiceMice, KnockoutOxidation-ReductionPeriodontitisPorphyromonas gingivalisAcetaldehydeAntibodies, MonoclonalEpitopes, B-LymphocyteFimbriae ProteinsGingipain Cysteine EndopeptidasesImmunoglobulin GLipoproteins, LDLMalondialdehydeReceptors, LDLReceptors, Pattern RecognitionAtherosclerosismalondialdehyde acetaldehydenatural AbperiodontitisPorphyromonas gingivalis

Identifiers

PMID33445998
PMCPMC7882809
OpenAlexW3119831007

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.