Evidence map›Paper›PMID 33445953›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias

Amyloid Precursor Protein Variant, E665D, Associated With Unique Clinical and Biomarker Phenotype.

Justin R Abbatemarco, Stephen E Jones, Mykol Larvie, Lynn M Bekris, Maria E Khrestian, Kamini Krishnan, James B Leverenz

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Justin R AbbatemarcoMellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, 2569Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID 0000-0003-1668-4753
Stephen E JonesMellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, 2569Cleveland Clinic Foundation, Cleveland, OH, USA.
Mykol LarvieImaging Sciences, Imaging Institute, 2569Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-4235-3624
Lynn M BekrisLerner Research Institute, Genomics Medicine Institute, 2569Cleveland Clinic, Cleveland, OH, USA.
Maria E KhrestianLerner Research Institute, Genomics Medicine Institute, 2569Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-1621-4711
Kamini KrishnanDepartment of Neurology, 2569Cleveland Clinic, Cleveland, OH, USA.
James B LeverenzLou Ruvo Center for Brain Health, Neurological Institute, 2569Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Dementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6M
Translational Therapeutics CoreP30AG062428 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI BEKRIS, LYNN · 2019 to 2020
$5.0M
International Lewy Body Dementia ConferenceR13NS111954 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI LEVERENZ, JAMES BRUCE · 2019 to 2019
$20k
NIA NIH HHS P30 AG062428NINDS NIH HHS R13 NS111954NINDS NIH HHS U01 NS100610
6 · The paper itself

Abstract

We describe a clinical, imaging and biomarker phenotype associated with an amyloid precursor gene

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorCerebral Amyloid AngiopathyAmyloid beta-PeptidesBiomarkersHumansMaleMiddle AgedPhenotypeAmyloid beta-PeptidesAmyloid beta-Protein PrecursorBiomarkersamyloid precursor proteincerebral amyloid angiopathyearly onset Alzheimer’s diseaseleukodystrophy

Identifiers

PMID33445953
PMCPMC10580711
OpenAlexW3118999301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.