Evidence map›Paper›PMID 33445656›Full record

ArticleBiomolecules2021

Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells.

Francesca Perut, Laura Roncuzzi, Sofia Avnet, Annamaria Massa, Nicoletta Zini, Silvia Sabbadini, Francesca Giampieri, Bruno Mezzetti, Nicola Baldini

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 2 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 2 syntheses or guidelines pooled it, 294 citations in OpenAlex.

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  5. Polygonum cuspidatum Exosome-Like Nanovesicles Alleviate Hypoxic Pulmonary Hypertension by Stabilizing PON1 to Inhibit MAPK-Mediated PASMC Phenotypic Switching.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Francesca PerutBST Biomedical Sciences and Technologies Lab, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-3783-7803
Laura RoncuzziBST Biomedical Sciences and Technologies Lab, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Sofia AvnetBST Biomedical Sciences and Technologies Lab, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-7843-0591
Annamaria MassaBST Biomedical Sciences and Technologies Lab, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Nicoletta ZiniCNR Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", Unit of Bologna, 40100 Bologna, Italy.
Silvia SabbadiniDepartment of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, 60121 Ancona, Italy.ORCID 0000-0002-2740-5708
Francesca GiampieriDepartment of Clinical Specialistic and Odontostomatological Sciences, University Politecnica delle Marche, 60121 Ancona, Italy.ORCID 0000-0002-8151-9132
Bruno MezzettiDepartment of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, 60121 Ancona, Italy.ORCID 0000-0001-9307-812X
Nicola BaldiniBST Biomedical Sciences and Technologies Lab, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Istituto Ortopedico Rizzoli · ITMarche Polytechnic University · IT

Funding

Italian Ministry of the Health, Financial Support for Scientific Research 5 per 1000MIUR-PRIN2017 national program 20173LBZM2
6 · The paper itself

Abstract

Plant-derived exosome-like nanovesicles (EPDENs) have recently been isolated and evaluated as potential bioactive nutraceutical biomolecules. It has been hypothesized that EPDENs may exert their activity on mammalian cells through their specific cargo. In this study, we isolated and purified EPDENs from the strawberry juice of

Indexed as

Oxidative StressAntioxidantsAscorbic AcidCell SurvivalExosomesFragariaHumansMesenchymal Stem CellsMicroRNAsNanoparticlesParticle SizeReactive Oxygen SpeciesAntioxidantsAscorbic AcidMicroRNAsReactive Oxygen Speciesascorbic acidedible plant-derived exosome-like nanoparticles (EPDENs)extracellular vesicles (EVs)Fragaria x ananassamesenchymal stromal cellsmiRNAoxidative stress

Identifiers

PMID33445656
PMCPMC7828105
OpenAlexW3120473476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.