Evidence map›Paper›PMID 33445611›Full record

ArticleMolecules (Basel, Switzerland)2021

Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson's Disease.

Gabriel Gonzalez, Jiří Grúz, Cosimo Walter D'Acunto, Petr Kaňovský, Miroslav Strnad

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  6. Photoprotective properties of new derivatives of kinetin.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gabriel GonzalezLaboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, and Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic.ORCID 0000-0002-8196-878X
Jiří GrúzLaboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, and Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic.
Cosimo Walter D'AcuntoLaboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, and Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic.
Petr KaňovskýDepartment of Neurology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, CZ-775 20 Olomouc, Czech Republic.
Miroslav StrnadLaboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, and Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic.
University Hospital Olomouc · CZCzech Academy of Sciences, Institute of Experimental Botany · CZ

Funding

Internal Grant Agency of Palacký University in Olomouc, Czech Republic IGA_PrF_2020_021student grant from Palacký University's Endowment Fund 2017The Czech Grant Agency 20-15621SThe European Regional Development Fund - Project ENOCH CZ.02.1.01/0.0/0.0/16_019/0000868
6 · The paper itself

Abstract

Cytokinins are adenine-based phytohormones that regulate key processes in plants, such as cell division and differentiation, root and shoot growth, apical dominance, branching, and seed germination. In preliminary studies, they have also shown protective activities against human neurodegenerative diseases. To extend knowledge of the protection (protective activity) they offer, we investigated activities of natural cytokinins against salsolinol (SAL)-induced toxicity (a Parkinson's disease model) and glutamate (Glu)-induced death of neuron-like dopaminergic SH-SY5Y cells. We found that kinetin-3-glucoside,

Indexed as

Models, BiologicalAcetylcysteineCaspase 3Caspase 7Cell DeathCell DifferentiationCell Line, TumorCytokininsGlutamic AcidHumansIsoquinolinesNeuronsNeuroprotective AgentsOxidative StressOxygenParkinson DiseaseAcetylcysteineCaspase 3Caspase 7CytokininsGlutamic AcidIsoquinolinesNeuroprotective AgentsOxygenPlant Growth RegulatorssalsolinolSuperoxidescytokinincytotoxicityglutamateneuron-like SH-SY5Y cellsneuroprotectionoxidative stressParkinson’s diseasephytohormonesalsolinol

Identifiers

PMID33445611
PMCPMC7827283
OpenAlexW3118686717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.