Evidence map›Paper›PMID 33445584›Full record

ArticleMolecules (Basel, Switzerland)2021

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream

Cecilia Ortíz, Francesca Moraca, Marc Laverriere, Allan Jordan, Niall Hamilton, Marcelo A Comini

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Evaluation of the Anti-Biomedicines · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Cecilia OrtízRedox Biology of Trypanosomes, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay.
Francesca MoracaDipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Marc LaverriereInstituto de Investigaciones Biotecnológicas, Instituto Tecnológico de Chascomus (IIB-INTECH, UNSAM-CONICET), Av. General Paz 5445, INTI, San Martín 1650, Pcia de Buenos Aires, Argentina.
Allan JordanDrug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, UK.ORCID 0000-0003-3449-3993
Niall HamiltonDrug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, UK.
Marcelo A CominiRedox Biology of Trypanosomes, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay.ORCID 0000-0001-5000-1333
Institut Pasteur de Montevideo · UYUniversity of Manchester · GBConsejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Siena · IT

Funding

Cancer Research UK 17098
6 · The paper itself

Abstract

Glucose 6-phosphate dehydrogenase (G6PDH) fulfills an essential role in cell physiology by catalyzing the production of NADPH

Indexed as

Life Cycle StagesAndrosteroneBinding SitesCytosolDehydroepiandrosteroneGlucosephosphate DehydrogenaseHumansModels, MolecularOxidation-ReductionReproducibility of ResultsSteroidsTrypanosoma brucei bruceiAndrosteroneDehydroepiandrosteroneGlucosephosphate DehydrogenaseSteroidsandrostanepentose phosphate pathwayredoxTrypanosoma bruceiTrypanosoma cruzi

Identifiers

PMID33445584
PMCPMC7826790
OpenAlexW3118958745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.