Evidence map›Paper›PMID 33445578›Full record

ArticleGenes2021

Elevated Expression of

Mathis Hildonen, Amanda M Levy, Christina Dahl, Victoria A Bjerregaard, Lisbeth Birk Møller, Per Guldberg, Nanette M Debes, Zeynep Tümer

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Mechanisms of Action ofDegenerative neurological and neuromuscular disease · 2022
    Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Mathis HildonenKennedy Center, Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark.ORCID 0000-0002-2016-3670
Amanda M LevyKennedy Center, Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark.
Christina DahlDanish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Victoria A BjerregaardKennedy Center, Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark.
Lisbeth Birk MøllerKennedy Center, Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark.ORCID 0000-0002-9524-4301
Per GuldbergDanish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Nanette M DebesTourette Clinics, Department of Paediatrics, Copenhagen University Hospital, 2730 Herlev, Denmark.
Zeynep TümerKennedy Center, Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark.ORCID 0000-0002-4777-5802
Copenhagen University Hospital · DKDanish Cancer Society · DKRoskilde University · DKUniversity of Copenhagen · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gilles de la Tourette syndrome (GTS) is a complex neurodevelopmental disorder characterized by motor and vocal tics. Most of the GTS individuals have comorbid diagnoses, of which obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD) are the most common. Several neurotransmitter systems have been implicated in disease pathogenesis, and amongst these, the dopaminergic and the serotonergic pathways are the most widely studied. In this study, we aimed to investigate whether the serotonin transporter (SERT) gene (

Indexed as

Gene Expression RegulationMutation, MissensePolymorphism, GeneticSerotonin Plasma Membrane Transport ProteinsTourette SyndromeAmino Acid SubstitutionAttention Deficit Disorder with HyperactivityHumansMaleObsessive-Compulsive DisorderSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human5-HTTexpressionGilles de la Tourette syndromeGTSmethylationobsessive compulsive disorderOCDserotoninSERTSLC6A4

Identifiers

PMID33445578
PMCPMC7827645
OpenAlexW3120976946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.