Evidence map›Paper›PMID 33445545›Full record

ReviewNanomaterials (Basel, Switzerland)2021

Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery.

Dawin Khiev, Zeinab A Mohamed, Riddhi Vichare, Ryan Paulson, Sofia Bhatia, Subhra Mohapatra, Glenn P Lobo, Mallika Valapala, Nagaraj Kerur, Christopher L Passaglia and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 168 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Nanotechnology-Based Treatment for Ophthalmic Diseases.International journal of nanomedicine · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Nanoparticles in intraocular drug delivery.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
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  18. Review
  19. Review
  20. Role of Nanoformulations in the Treatment of Lung Cancer.Recent patents on nanotechnology · 2025
    Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Dawin KhievMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Zeinab A MohamedMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Riddhi VichareMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Ryan PaulsonDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Sofia BhatiaDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Subhra MohapatraDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Glenn P LoboDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Mallika ValapalaSchool of Optometry, Indiana University, Bloomington, IN 47401, USA.
Nagaraj KerurDepartment of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Christopher L PassagliaDepartment of Medical Engineering, College of Engineering, Tampa, FL 33620, USA.
Shyam S MohapatraMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0001-5838-0681
Manas R BiswalMSPN Graduate Programs, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
University of South Florida · USIndiana University Bloomington · USMedical University of South Carolina · USUniversity of Tampa · USUniversity of Virginia · US

Funding

Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationR00EY027013 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI BISWAL, MANAS R · 2019 to 2021
$960k
Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationK99EY027013 · NEI · UNIVERSITY OF FLORIDA · PI BISWAL, MANAS R · 2016 to 2017
$258k
BLRD VA IK6 BX004212NEI NIH HHS EY027013-02University of South Florida Taneja College of Pharmacy Start up
6 · The paper itself

Abstract

Ocular diseases can deteriorate vision to the point of blindness and thus can have a major impact on the daily life of an individual. Conventional therapies are unable to provide absolute therapy for all ocular diseases due to the several limitations during drug delivery across the blood-retinal barrier, making it a major clinical challenge. With recent developments, the vast number of publications undergird the need for nanotechnology-based drug delivery systems in treating ocular diseases. The tool of nanotechnology provides several essential advantages, including sustained drug release and specific tissue targeting. Additionally, comprehensive in vitro and in vivo studies have suggested a better uptake of nanoparticles across ocular barriers. Nanoparticles can overcome the blood-retinal barrier and consequently increase ocular penetration and improve the bioavailability of the drug. In this review, we aim to summarize the development of organic and inorganic nanoparticles for ophthalmic applications. We highlight the potential nanoformulations in clinical trials as well as the products that have become a commercial reality.

Indexed as

clinical trialsophthalmic applicationsorganic and inorganic nanoparticles

Identifiers

PMID33445545
PMCPMC7828028
OpenAlexW3119705211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.