ArticleAntioxidants (Basel, Switzerland)2021
Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Clinical characteristics of Papillon-Lefèvre syndrome: A KSA perspective.Journal of Taibah University Medical Sciences · 2025Review
- Papillon-Lefèvre syndrome in dental pediatric patient: A comprehensive review.The Saudi dental journal · 2024Review
- TFAM-deficient mouse skin fibroblasts - an ex vivo model of mitochondrial dysfunction.Disease models & mechanisms · 2021Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) gene, characterized by periodontitis and palmoplantar hyperkeratosis. The main inflammatory deficiencies include oxidative stress and autophagic dysfunction. Mitochondria are the main source of reactive oxygen species; their impaired function is related to skin diseases and periodontitis. The mitochondrial function has been evaluated in PLS and mitochondria have been targeted as a possible treatment for PLS. We show for the first time an important mitochondrial dysfunction associated with increased oxidative damage of mtDNA, reduced CoQ10 and mitochondrial mass and aberrant morphologies of the mitochondria in PLS patients. Mitochondrial dysfunction, determined by oxygen consumption rate (OCR) in PLS fibroblasts, was treated with CoQ10 supplementation, which determined an improvement in OCR and a remission of skin damage in a patient receiving a topical administration of a cream enriched with CoQ10 0.1%. We provide the first evidence of the role of mitochondrial dysfunction and CoQ10 deficiency in the pathophysiology of PLS and a future therapeutic option for PLS.
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