Evidence map›Paper›PMID 33445463›Full record

ArticleMicroorganisms2021

Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense.

Wei He, Juan Li, Ai-Yu Gong, Silu Deng, Min Li, Yang Wang, Nicholas W Mathy, Yaoyu Feng, Lihua Xiao, Xian-Ming Chen

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Deciphering Host-Pathogen Interactions: Role ofPathogens (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Current research in parasitology & vector-borne diseases · 2025
    Article
  5. Article
  6. Article
  7. Early immune and host cell responses toFrontiers in parasitology · 2023
    Article
  8. Article
  9. IsFood and waterborne parasitology · 2022
    Article
  10. PersistentMicroorganisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Wei HeCenter for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-8568-7926
Juan LiDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68198-5880, USA.
Ai-Yu GongDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68198-5880, USA.
Silu DengDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68198-5880, USA.
Min LiDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68198-5880, USA.
Yang WangDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68198-5880, USA.
Nicholas W MathyDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68198-5880, USA.
Yaoyu FengCenter for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-8380-1246
Lihua XiaoCenter for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0001-8532-2727
Xian-Ming ChenDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68198-5880, USA.
Creighton University · USSouth China Agricultural University · CN

Funding

Molecular Basis of Intestinal CryptosporidiosisR01AI116323 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2015 to 2025
$4.2M
LincRNAs in Mucosal Defense to AIDS Opportunistic Pathogen CryptosporidiumR01AI136877 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2018 to 2022
$1.9M
Intestinal Stem Cell Responses to Cryptosporidium InfectionR21AI141325 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2020 to 2021
$415k
Nebraska Cancer and Smoking Disease Research Program LB595NIAID NIH HHS R01 AI116323NIAID NIH HHS R01 AI136877NIAID NIH HHS R21 AI141325NIH HHS AI116323, AI136877, AI141325
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cryptosporidiosisCryptosporidiumdefenseintestinal epitheliumMAPKp38/MAPK

Identifiers

PMID33445463
PMCPMC7826584
OpenAlexW3119414312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.