Evidence map›Paper›PMID 33445445›Full record

ArticleMarine drugs2021

Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid

Ana P Rodrigo, Vera M Mendes, Bruno Manadas, Ana R Grosso, António P Alves de Matos, Pedro V Baptista, Pedro M Costa, Alexandra R Fernandes

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ana P RodrigoUCIBIO-Applied Molecular Biosciences Unit, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0001-9310-4447
Vera M MendesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3060-197 Cantanhede, Portugal.
Bruno ManadasCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3060-197 Cantanhede, Portugal.ORCID 0000-0002-2087-4042
Ana R GrossoUCIBIO-Applied Molecular Biosciences Unit, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0001-6974-4209
António P Alves de MatosCentro de Investigação Interdisciplinar Egas Moniz (CiiEM), Quinta da Granja, Monte de Caparica, 2829-516 Caparica, Portugal.
Pedro V BaptistaUCIBIO-Applied Molecular Biosciences Unit, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0001-5255-7095
Pedro M CostaUCIBIO-Applied Molecular Biosciences Unit, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0002-9072-3522
Alexandra R FernandesUCIBIO-Applied Molecular Biosciences Unit, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0003-2054-4438
Universidade Nova de Lisboa · PTUniversity of Coimbra · PTEscola Superior de Saúde Egas Moniz · PT

Funding

Fundação para a Ciência e a Tecnologia CEECIND/02699/2017Fundação para a Ciência e a Tecnologia PTDC/BTA-BTA/28650/2017Fundação para a Ciência e a Tecnologia PTDC/BTM-TEC/29311/2017Fundação para a Ciência e a Tecnologia PTDC/MEC-PSQ/30943/2017Fundação para a Ciência e a Tecnologia SAICTPAC/0010/2015Fundação para a Ciência e a Tecnologia SFRH/BD/109462/2015Fundação para a Ciência e a Tecnologia UID/NEU/04539/2019National Mass Spectrometry Network (RNEM) ROTEIRO/0028/2013
6 · The paper itself

Abstract

As Yondelis joins the ranks of approved anti-cancer drugs, the benefit from exploring the oceans' biodiversity becomes clear. From marine toxins, relevant bioproducts can be obtained due to their potential to interfere with specific pathways. We explored the cytotoxicity of toxin-bearing secretions of the polychaete

Indexed as

AnnelidaAnimalsAntineoplastic AgentsApoptosisCell ProliferationCell SurvivalDose-Response Relationship, DrugFemaleHCT116 CellsHumansK562 CellsMarine ToxinsMCF-7 CellsOvarian NeoplasmsAntineoplastic AgentsMarine Toxinscancercell cyclecytotoxicityinvertebrateovarian cancerprogrammed cell deathtoxin

Identifiers

PMID33445445
PMCPMC7827603
OpenAlexW3120250126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.