Evidence map›Paper›PMID 33445084›Full record

ArticleJournal of affective disorders2021

Biopsychosocial correlates of psychological distress in Latina mothers.

Hudson P Santos, Harry Adynski, Rebeca Harris, Arjun Bhattacharya, Angela C Incollingo Rodriguez, Ryan Cali, Alessandra Torres Yabar, Benjamin C Nephew, Christopher Murgatroyd

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026
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  13. Women during Lactation Reduce Their Physical Activity and Sleep Duration Compared to Pregnancy.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Hudson P SantosBiobehavioral Laboratory, School of Nursing, University of North Carolina at Chapel Hill, NC, United States. Electronic address: hsantos@unc.edu.
Harry AdynskiBiobehavioral Laboratory, School of Nursing, University of North Carolina at Chapel Hill, NC, United States.
Rebeca HarrisBiobehavioral Laboratory, School of Nursing, University of North Carolina at Chapel Hill, NC, United States.
Arjun BhattacharyaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Angela C Incollingo RodriguezPsychological & Cognitive Sciences, Worcester Polytechnic Institute, MA, United States.
Ryan CaliDepartment of Psychiatry, University of Massachusetts Medical School, MA, United States.
Alessandra Torres YabarDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, MA, United States.
Benjamin C NephewDepartment of Psychiatry, University of Massachusetts Medical School, MA, United States; Department of Biology and Biotechnology, Worcester Polytechnic Institute, MA, United States.
Christopher MurgatroydSchool of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom.
University of North Carolina at Chapel Hill · USWorcester Polytechnic Institute · USManchester Metropolitan University · GBUniversity of California, Los Angeles · USUniversity of Massachusetts Chan Medical School · US

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
NCATS NIH HHS UL1 TR002489
6 · The paper itself

Abstract

backgroundFew studies have explored the relationship between psychological, psychosocial and biological factors among Latinas. An integrated understanding of how these factors associate with psychological distress is necessary for the development of culturally relevant screening tools and interventions. The study aim was to examine the relationships among (a) psychological distress symptoms, (b) psychosocial factors (discrimination, acculturation, acculturative stress, economic hardship), and (c) biological (DNA methylation of stress-related genes) factors among Latinas during pregnancy and postpartum period.

methodsA sample of 150 pregnant Latinas completed the Inventory of Depression and Anxiety Symptoms II (IDAS-II), psychosocial questionnaires (discrimination, acculturation, acculturative stress, economic hardship) before (24-32 weeks) and after gestation (4-6 weeks postpartum). Blood samples were collected between 24-32 weeks gestation. Correlations were determined between psychosocial and biological measures and psychological distress measures. Multivariable linear regression models were conducted to assess the relationships between IDAS and stressors.

resultsSeveral correlations among psychosocial measures,DNA methylation factors and IDAS-II variables were identified. Among the psychosocial measures, everyday discrimination was the most strongly and consistently associated with IDAS-II. DNA methylation of NR3C1 affects the associations between psychological and psychosocial distress. LIMITATIONS: We only assessed DNA methylation during pregnancy and focused on four HPA-related genes. Longitudinal assessment of DNA methylation and genome-wide analysis can provide a better picture of the role of methylation in psychological distress.

conclusionsThis work may assist clinicians and policy makers in effectively recognizing and preventing maternal mental health disparities based on discrimination and other psychosocial stressors in at-risk groups.

Indexed as

MothersPsychological DistressDepressionFemaleHispanic or LatinoHumansPostpartum PeriodPregnancyStress, PsychologicalBiomarkersDNA methylationLatinasPostpartumPrenatalPsychological distress

Identifiers

PMID33445084
PMCPMC7889736
OpenAlexW3117594828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.