SynthesisDrug and alcohol dependence2021
Systematic review and meta-analysis of socio-cognitive and socio-affective processes association with adolescent substance use.
Synthesis in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Social cognition in Korsakoff's syndrome: A meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- The prevalence and influencing factors of psychotic-like experiences in children and adolescents: a meta-analysis and systematic review.European child & adolescent psychiatry · 2026Pooled it
- Systematic review and meta-analysis on the association between theory of mind and alcohol problems in non-clinical samples.Alcoholism, clinical and experimental research · 2022Pooled it
- Meta-analysis of associations between empathy and alcohol use and problems in clinical and non-clinical samples.Addiction (Abingdon, England) · 2022Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- The impact of empathy on drinking motives, craving, and drink orders: An experimental study.Alcohol, clinical & experimental research · 2025Trial
- Affective theory of mind impairments linked with callous-unemotional traits implicate cognitive control: A pre-registered double-blind randomized controlled trial with a dual-task paradigm.Journal of affective disorders · 2025Trial
- Alcohol's acute effects on emotion recognition and empathy in heavy-drinking young adults.Scientific reports · 2025Trial
- Article
- Positive face BOLD response and task-dependent ventral striatal functional connectivity during Go/No-go task among abstinent cannabis-using adolescents and young adults.Frontiers in adolescent medicine · 2026Article
- Assessing the prevalence, determinants, and health impact of substance use among university students in Bangladesh.BMC public health · 2025Article
- Profiles of Intolerance of Uncertainty Among 108,540 Adolescents: Associations with Sociodemographic Variables and Mental Health.Child psychiatry and human development · 2025Article
- Comparison of Insomnia, Depression, and Perceived Social Support among Individuals with Amphetamine Use Disorder (AUD) and Healthy Controls.Alpha psychiatry · 2025Article
- Punishment and Reward Sensitivity in Risk-Taking as Potential Mechanisms Explaining the Relationships Between Childhood Callous-Unemotional Traits and Adolescent Substance Use in a Longitudinal Cohort Study Sample.Research on child and adolescent psychopathology · 2025Article
- Past-year substance use behaviors among university admission test-takers: insights from Bangladesh.BMC public health · 2024Article
- Impairments of Sociocognitive Functions in Individuals with Behavioral Addictions: A Review Article.Journal of gambling studies · 2024Review
- Addressing cortex dysregulation in youth through brain health check coaching and prophylactic brain development.INNOSC theranostics & pharmacological sciences · 2024Article
- Adolescent substance use outcomes in response to social consequences of use: the role of empathy.Journal of drug issues · 2024Article
- Efficiency of Heterogenous Functional Connectomes Explains Variance in Callous-Unemotional Traits After Computational Lesioning of Cortical Midline and Salience Regions.Brain connectivity · 2023Article
- Connectome-based predictive modeling of empathy in adolescents with and without the low-prosocial emotion specifier.Neuroscience letters · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSocial impairments are important features of a substance use disorder diagnosis; and recent models suggest early impairments in socio-cognitive and -affective processes may predict future use. However, no systematic reviews are available on this topic.
methodsWe conducted a systematic review and meta-analyses exploring the association between social-cognitive and -affective processes (empathy, callous-unemotional (CU) traits, theory of mind, and social cognition) and substance use frequency (alcohol, cannabis, general drug use). We examined moderating effects of study design, gender, age, and weather conduct problems were controlled for. We also review brain studies related to social cognition and substance use disorder (SUD) risk.
resultsSystematic review suggested a negative association for positively valenced constructs with substance use but mixed results on the negatively valenced construct CU traits. Meta-analyses revealed moderate positive association between CU traits with alcohol and general drug use but no significance with cannabis use. Moderate effect sizes were found for CU traits in youth predicting severity of substance use by late adolescence and significantly accounted for variance independently of conduct problems. Significant moderators included gender proportions, sample type, and age. Neuroimaging meta-analysis indicated 10 coordinates that were different in youth at a high risk/with SUD compared to controls. Three of these coordinates associate with theory of mind and social cognition.
conclusionSocio-cognitive and -affective constructs demonstrate an association with current and future substance use, and neural differences are present when performing social cognitive tasks in regions with strongest associations with theory of mind and social cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.