ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2021
Bats are key hosts in the radiation of mammal-associated Bartonella bacteria.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 48 citations in OpenAlex.
- Characterisation of Typical Enteropathogenic Escherichia coli (tEPEC) and bfpA Genes From Five Bat Species Reveals Australian Pteropus Spp. Are Natural tEPEC Hosts.MicrobiologyOpen · 2026Article
- Wild canids as reservoirs of zoonotic Bartonella species in Israel.Parasites & vectors · 2026Article
- Urea transporter evolution: deep conservation, recent adaptation in mammals, and maintenance of the Jka/Jkb polymorphism in the past ~ 110,000 years.Biology direct · 2026Article
- A general framework for modeling pathogen transmission in co-roosting host communities.Ecology · 2026Article
- Genome-Wide Association Reveals Signalling-Linked Infection Tolerance in Hibernating Bats.Pathogens (Basel, Switzerland) · 2026Article
- Host-Driven Genetic Diversity ofTransboundary and emerging diseases · 2026Article
- Microbial network assembly in bat flies with differing host specificity from North Africa.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Genomic characterization of eight novel Bartonella species from bats and ectoparasites reveals phylogenetic diversity and host adaptation.PLoS neglected tropical diseases · 2025Article
- Holobiont-holobiont interactions across host-ectoparasite systems.Parasites & vectors · 2025Review
- Article
- Molecular Detection and Isolation ofTransboundary and emerging diseases · 2025Article
- From host individual traits to community structure and composition: Bartonella infection insights.Parasites & vectors · 2024Article
- Geographically widespread and novel hemotropic mycoplasmas and bartonellae in Mexican free-tailed bats and sympatric North American bat species.bioRxiv : the preprint server for biology · 2024Article
- Molecular detection of Bartonella spp. in bat-associated macronyssid mites (Acari: Macronyssidae) from Southern and Southeastern Brazil.Veterinary research communications · 2024Article
- Molecular prevalence ofHeliyon · 2024Article
- Bartonella in bat flies from the Egyptian fruit bat in the Middle East.Parasitology research · 2024Article
- Review
- Detection of bacterial and protozoan pathogens in individual bats and their ectoparasites using high-throughput microfluidic real-time PCR.Microbiology spectrum · 2023Article
- Molecular Detection and Genotyping of Cryptosporidium spp. Isolates from Bats in Colombia.Acta parasitologica · 2023Article
- Genomic Characterization of Three NovelMicroorganisms · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Bats are notorious reservoirs of several zoonotic diseases and may be uniquely tolerant of infection among mammals. Broad sampling has revealed the importance of bats in the diversification and spread of viruses and eukaryotes to other animal hosts. Vector-borne bacteria of the genus Bartonella are prevalent and diverse in mammals globally and recent surveys have revealed numerous Bartonella lineages in bats. We assembled a sequence database of Bartonella strains, consisting of nine genetic loci from 209 previously characterized Bartonella lineages and 121 new cultured isolates from bats, and used these data to perform a comprehensive phylogenetic analysis of the Bartonella genus. This analysis included estimation of divergence dates using a molecular clock and ancestral reconstruction of host associations and geography. We estimate that Bartonella began infecting mammals 62 million years ago near the Cretaceous-Paleogene boundary. Additionally, the radiation of particular Bartonella clades correlate strongly to the timing of diversification and biogeography of mammalian hosts. Bats were inferred to be the ancestral hosts of all mammal-associated Bartonella and appear to be responsible for the early geographic expansion of the genus. We conclude that bats have had a deep influence on the evolutionary radiation of Bartonella bacteria and their spread to other mammalian orders. These results support a 'bat seeding' hypothesis that could explain similar evolutionary patterns in other mammalian parasite taxa. Application of such phylogenetic tools as we have used to other taxa may reveal the general importance of bats in the ancient diversification of mammalian parasites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.