ArticlePloS one2021
Potential role of the skin and gut microbiota in premenarchal vulvar lichen sclerosus: A pilot case-control study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05147129 (Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen Sclerosus), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen Sclerosus
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pediatric Vulvar Lichen Sclerosus-A Review of the Literature.International journal of environmental research and public health · 2021Pooled it
- Postbiotics originated from Lactobacillus crispatus NCU-31 improves vulvar lichen sclerosus: a randomized, double-blind controlled trial.BMC microbiology · 2026Trial
- Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia.BioMed research international · 2021Trial
- Noninvasive physical plasma in vulvar lichen sclerosus: a prospective pilot study.International journal of women's dermatology · 2026Article
- Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures.Microbiology spectrum · 2025Article
- Genital Lichen Sclerosus-The Role of the Vulvar Microbiome.Medicina (Kaunas, Lithuania) · 2025Article
- Cutaneous dysbiosis in girls with vulvar lichen sclerosus.Microbiology spectrum · 2025Article
- Article
- Vulvar Lichen Sclerosus: A Literature Review with Consideration of Integrative Therapies.Integrative medicine (Encinitas, Calif.) · 2025Review
- Taxonomic and functional profiling of the vulvar microbiome indicates variations related to ecological signatures, aging, and health status.Frontiers in microbiology · 2025Article
- Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution.Journal of inflammation research · 2025Article
- Optimisation of cutaneous microbiota sampling methodology.Frontiers in microbiomes · 2025Article
- Lack of oral involvement in a large cohort of women with vulvar lichen sclerosus - a multicenter prospective study.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2024Observational
- The relationship between the vaginal and vulvar microbiomes and lichen sclerosus symptoms in post-menopausal women.Scientific reports · 2024Article
- Alternations in the human skin, gut and vaginal microbiomes in perimenopausal or postmenopausal Vulvar lichen sclerosus.Scientific reports · 2024Article
- Advances in the pathogenesis of vulvar lichen sclerosus.Molecular biology reports · 2024Review
- Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony.Frontiers in nutrition · 2024Review
- The vulvar microbiome in lichen sclerosus and high-grade intraepithelial lesions.Frontiers in microbiology · 2023Article
- Role of gut microbiota in infectious and inflammatory diseases.Frontiers in microbiology · 2023Review
- The Skin and Gut Microbiome in Hidradenitis Suppurativa: Current Understanding and Future Considerations for Research and Treatment.American journal of clinical dermatology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
The etiology of vulvar lichen sclerosus (LS) remains unclear; however, alterations in cutaneous and gut microbiota may be contributing to the pathogenesis of this inflammatory condition. To explore this hypothesis, we conducted a pilot case-control study, obtaining dermal swab and stool samples from prepubertal girls with vulvar LS (n = 5), girls with nonspecific vulvovaginitis (n = 5), and healthy controls (n = 3). Samples (n = 56) were subjected to total DNA extractions. Resulting DNA was purified, subjected to PCR (targeting the V3V4 region of the 16S rRNA gene), sequenced, and analyzed using QIIME, MetagenomeSeq, and DESeq2 software packages. Our findings showed that there were significant differences in the cutaneous and gut microbiotas of girls with LS compared to controls. On the skin, girls with LS had a statistically significantly higher relative abundance of Porphyromonas spp., Parvimonas spp., Peptoniphilus spp., Prevotella spp., Dialister spp., and Peptostreptococcus spp., but a lower relative abundance of Cornyebacterium compared to the control group. In the gut samples, girls with LS had a significantly higher relative abundance of Dialister spp., Clostridiales spp., Paraprevotella spp., Escherichia coli, Bifidobacterium adolescentis, and Akkermansia muciniphila, and a lower relative abundance of Roseburia faecis and Ruminococcus bromii compared to controls. These results suggest a potential association between cutaneous and gut dysbiosis and pediatric vulvar LS. Future studies involving larger samples sizes are warranted to further evaluate this association.
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Registered trials
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