Evidence map›Paper›PMID 33444356›Full record

ArticlePloS one2021

Modeling the initial phase of SARS-CoV-2 deposition in the respiratory tract mimicked by the 11C radionuclide.

Heitor Evangelista, César Amaral, Luís Cristóvão Porto, Sérgio J Gonçalves Junior, Eduardo Delfino Sodré, Juliana Nogueira, Angela M G Dos Santos, Marcio Cataldo, Daniel Junger

Abstract read
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In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heitor EvangelistaLARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
César AmaralLARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
Luís Cristóvão PortoHLA - Laboratório de Histocompatibilidade e Criopreservação, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
Sérgio J Gonçalves JuniorLARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-1852-0894
Eduardo Delfino SodréLARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
Juliana NogueiraLARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0003-4858-8774
Angela M G Dos SantosHLA - Laboratório de Histocompatibilidade e Criopreservação, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
Marcio CataldoDraxos Consultoria e Gestão Ambiental Ltda., Rio de Janeiro, Rio de Janeiro, Brazil.
Daniel JungerLARAMG - Laboratory of Radioecology and Global Changes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The knowledge on the deposition and retention of the viral particle of SARS-CoV-2 in the respiratory tract during the very initial intake from the ambient air is of prime importance to understand the infectious process and COVID-19 initial symptoms. We propose to use a modified version of a widely tested lung deposition model developed by the ICRP, in the context of the ICRP Publication 66, that provides deposition patterns of microparticles in different lung compartments. In the model, we mimicked the "environmental decay" of the virus, determined by controlled experiments related to normal speeches, by the radionuclide 11C that presents comparable decay rates. Our results confirm clinical observations on the high virus retentions observed in the extrathoracic region and the lesser fraction on the alveolar section (in the order of 5), which may shed light on physiopathology of clinical events as well on the minimal inoculum required to establish infection.

Indexed as

AerosolsCarbon RadioisotopesCOVID-19HumansLungModels, BiologicalRespiratory SystemSARS-CoV-2AerosolsCarbon-11Carbon Radioisotopes

Identifiers

PMID33444356
PMCPMC7808619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.