ArticlePloS one2021
Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Efficacy of IVIG therapy for patients with sepsis: a systematic review and meta-analysis.Journal of translational medicine · 2023Pooled it
- Impact evaluation of a digital health platform empowering Kenyan women across the pregnancy-postpartum care continuum: A cluster randomized controlled trial.PLoS medicine · 2025Trial
- The effect of a planned lactation education program on the mother's breastfeeding practice and weight gain in low birth weight infants: a randomized clinical trial study.BMC pregnancy and childbirth · 2022Trial
- Etiology of severe invasive infections in young infants in rural settings in sub-Saharan Africa.PloS one · 2022Trial
- Time to Death and Predictors of Mortality in Neonates Admitted to Tibebe Ghion Referral Hospital, Neonatal Intensive Care Unit in Northwest Ethiopia: A Retrospective Follow-Up Study.Health science reports · 2026Article
- Neonatal mortality and survival of low-birth-weight infants at hospitals in indonesia, a multi center study.Scientific reports · 2025Article
- Analysis of anxiety and depression status and related factors among mothers of children in neonatal intensive care unit.World journal of psychiatry · 2025Article
- Special care baby unit neonatal disease outcomes in a tertiary hospital in Nigeria: 2-year retrospective cross-sectional analysis.BMJ public health · 2025Article
- Women's empowerment as a determinant of neonatal mortality in Sub-Saharan Africa: a narrative review focused on Nigeria.Global health action · 2024Review
- Development and Implementation of Digital Diagnostic Algorithms for Neonatal Units in Zimbabwe and Malawi: Development and Usability Study.JMIR formative research · 2024Article
- Time to full enteral feeds in hospitalised preterm and very low birth weight infants in Nigeria and Kenya.PloS one · 2024Article
- Correction: Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya.PloS one · 2024Article
- Molecular surveillance reveals widespread colonisation by carbapenemase and extended spectrum beta-lactamase producing organisms in neonatal units in Kenya and Nigeria.Antimicrobial resistance and infection control · 2023Article
- Article
- Neonatal Mortality and Associated Factors in the Neonatal Intensive Care Unit of Gadarif Hospital, Eastern Sudan.Children (Basel, Switzerland) · 2022Article
- Review
- Enteral Feeding Practices for Very Preterm and Very Low Birth Weight Infants in Nigeria and Kenya.Frontiers in pediatrics · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 10 institutions in 4 countries.
Funding
Abstract
objectiveTo describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria. STUDY
designIn a network of seven secondary and tertiary level neonatal units in Nigeria and Kenya, we captured anonymised data on all admissions <48 hours of age over a 6-month period.
results2280 newborns were admitted. Mean birthweight was 2.3 kg (SD 0.9); 57.0% (1214/2128) infants were low birthweight (LBW; <2.5kg) and 22.6% (480/2128) were very LBW (VLBW; <1.5 kg). Median gestation was 36 weeks (interquartile range 32, 39) and 21.6% (483/2236) infants were very preterm (gestation <32 weeks). The most common morbidities were jaundice (987/2262, 43.6%), suspected sepsis (955/2280, 41.9%), respiratory conditions (817/2280, 35.8%) and birth asphyxia (547/2280, 24.0%). 18.7% (423/2262) newborns died; mortality was very high amongst VLBW (222/472, 47%) and very preterm infants (197/483, 40.8%). Factors independently associated with mortality were gestation <28 weeks (adjusted odds ratio 11.58; 95% confidence interval 4.73-28.39), VLBW (6.92; 4.06-11.79), congenital anomaly (4.93; 2.42-10.05), abdominal condition (2.86; 1.40-5.83), birth asphyxia (2.44; 1.52-3.92), respiratory condition (1.46; 1.08-2.28) and maternal antibiotics within 24 hours before or after birth (1.91; 1.28-2.85). Mortality was reduced if mothers received a partial (0.51; 0.28-0.93) or full treatment course (0.44; 0.21-0.92) of dexamethasone before preterm delivery.
conclusionGreater efforts are needed to address the very high burden of illnesses and mortality in hospitalized newborns in sub-Saharan Africa. Interventions need to address priority issues during pregnancy and delivery as well as in the newborn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.