ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021
Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Blood Pressure Variability and Cerebral Perfusion Decline: A Post Hoc Analysis of the SPRINT MIND Trial.Journal of the American Heart Association · 2023Trial
- Aerobic exercise training reduces cerebrovascular impedance in older adults: a 1-year randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition.GeroScience · 2026Article
- Capillary stalling: A common microvascular pathway to stroke susceptibility and poor recovery.Neurobiology of disease · 2026Review
- Association of composite biomarkers with imaging burden in cerebral small vessel disease.Lipids in health and disease · 2026Article
- MVP-VSASL: measuring MicroVascular Pulsatility using velocity-selective arterial spin labeling.Magnetic resonance in medicine · 2025Article
- Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study.Frontiers in aging neuroscience · 2025Article
- Blood-brain barrier integrity is linked to cognitive function, but not to cerebral arterial pulsatility, among elderly.Scientific reports · 2024Article
- Four-dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities.NMR in biomedicine · 2024Review
- Measuring pulsatile cortical blood flow and volume during carotid endarterectomy.Biomedical optics express · 2024Article
- Paravascular fluid dynamics reveal arterial stiffness assessed using dynamic diffusion-weighted imaging.NMR in biomedicine · 2024Article
- Review of theories into the pathogenesis of normal pressure hydrocephalus.BMJ neurology open · 2024Review
- Normative Cerebral Hemodynamics in Middle-aged and Older Adults Using 4D Flow MRI: Initial Analysis of Vascular Aging.Radiology · 2023Article
- Effect of long-term antihypertensive treatment on cerebrovascular structure and function in hypertensive rats.Scientific reports · 2023Article
- Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis.Frontiers in endocrinology · 2023Review
- Measuring brain beats: Cardiac-aligned fast functional magnetic resonance imaging signals.Human brain mapping · 2023Article
- Longitudinal stability in working memory and frontal activity in relation to general brain maintenance.Scientific reports · 2022Article
- Motion-corrected 4D-Flow MRI for neurovascular applications.NeuroImage · 2022Article
- 5-Year Associations among Cerebral Arterial Pulsatility, Perivascular Space Dilation, and White Matter Lesions.Annals of neurology · 2022Article
- Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocampal volume. However, evidence linking features of the cerebral arterial flow waveform to hippocampal function is lacking. We used a high-resolution 4D flow MRI approach to estimate global representations of the time-resolved flow waveform in distal cortical arteries and in proximal arteries feeding the brain in healthy older adults. Waveform-based clustering revealed a group of individuals featuring steep systolic onset and high amplitude that had poorer hippocampus-sensitive episodic memory (p = 0.003), lower whole-brain perfusion (p = 0.001), and weaker microvascular low-frequency oscillations in the hippocampus (p = 0.035) and parahippocampal gyrus (p = 0.005), potentially indicating compromised neurovascular unit integrity. Our findings suggest that aberrant hemodynamic forces contribute to cerebral microvascular and hippocampal dysfunction in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.