Evidence map›Paper›PMID 33443811›Full record

ArticleThe Laryngoscope2021

Drug-Induced Sleep Endoscopy and Hypoglossal Nerve Stimulation Outcomes: A Multicenter Cohort Study.

Phillip Huyett, David T Kent, Mark A D'Agostino, Katherine K Green, Ryan J Soose, Thomas M Kaffenberger, B Tucker Woodson, Colin Huntley, Maurits S Boon, Clemens Heiser and 5 more

2 registry-linked trialsOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in The Laryngoscope, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06372847 narecruitingnot on this mapstarted 2025, after this paper: background citation

Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on the Site of Collapse During DISE

TypeinterventionalSponsorUniversity Hospital, AntwerpRan2025 to 2028Enrolled58ConditionsObstructive Sleep ApneaArmsHypoglossal nerve stimulation implant, Polysomnography, Drug-induced sleep endoscopy (DISE)
NCT07724938 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal Collapse

TypeinterventionalSponsorBrigham and Women's HospitalRan2026 to 2031Enrolled72ConditionsObstructive Sleep Apnea, Sleep Disordered BreathingArmsTonsillectomy, HGNS
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 81 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Positive airway pressure-associated epiglottis-related obstruction in adult men with obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  8. Article
  9. Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024).World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  10. The upper airway in obstructive sleep apnoea: state of the art.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  11. Article
  12. Assessing ChatGPT Responses to Commonly Asked Questions About Hypoglossal Nerve Stimulation.World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  13. Article
  14. Persistent OSA After Maxillomandibular Advancement: Insights From Drug-Induced Sleep Endoscopy.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  15. Review
  16. Review
  17. Ascending and Descending Pharyngeal Opening Pressures During Drug-Induced Sleep Endoscopy: Mechanistic Insights for Sleep Surgeons.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  18. Observational
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 2 countries.

Phillip HuyettDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.ORCID 0000-0002-1951-3266
David T KentDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.
Mark A D'AgostinoSouthern New England Ear, Nose and Throat Group, Middlesex Hospital, Middlesex, Connecticut, U.S.A.ORCID 0000-0001-5878-5670
Katherine K GreenDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, Colorado, U.S.A.
Ryan J SooseUPMC Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
Thomas M KaffenbergerUPMC Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.ORCID 0000-0002-8411-6806
B Tucker WoodsonDepartment of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.ORCID 0000-0003-2396-2926
Colin HuntleyDepartment of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.ORCID 0000-0003-4637-3630
Maurits S BoonDepartment of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
Clemens HeiserDepartment of Otorhinolaryngology, Head and Neck Surgery, Technische Universität München, Munich, Germany.ORCID 0000-0001-6301-2891
Amelie BirkDepartment of Otorhinolaryngology, Head and Neck Surgery, Technische Universität München, Munich, Germany.
Maria V SuurnaDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine/New York Presbyterian Hospital, New York, New York, U.S.A.ORCID 0000-0002-7032-0902
Ho-Sheng LinDepartment of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan, U.S.A.
Jonathan A WaxmanDepartment of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan, U.S.A.ORCID 0000-0001-7706-7578
Eric J KezirianUSC Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of the University of Southern California, California, Los Angeles, U.S.A.ORCID 0000-0003-3808-4521
Technical University of Munich · DEThomas Jefferson University · USUniversity of Pittsburgh · USWayne State University · USCornell University · USMassachusetts Eye and Ear Infirmary · USMedical College of Wisconsin · USUniversity of Colorado Denver · USUniversity of Southern California · USVanderbilt University Medical Center · USYale University · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855
6 · The paper itself

Abstract

objectives/hypothesisTo determine the association between findings of blinded reviews of preoperative drug-induced sleep endoscopy (DISE) and outcomes of hypoglossal nerve stimulation (HNS) for obstructive sleep apnea (OSA). STUDY

designCohort study.

methodsA retrospective, multicenter cohort study of 343 adults who underwent treatment of OSA with HNS from 10 academic medical centers was performed. Preoperative DISE videos were scored by four blinded reviewers using the VOTE Classification and evaluation of a possible primary structure contributing to airway obstruction. Consensus DISE findings were examined for an association with surgical outcomes based on therapy titration polysomnogram (tPSG). Treatment response was defined by a decrease of ≥50% in the apnea-hypopnea index (AHI) to <15 events/hour.

resultsStudy participants (76% male, 60.4 ± 11.0 years old) had a body mass index of 29.2 ± 3.6 kg/m

conclusionsThe DISE finding of primary tongue contribution to airway obstruction was associated with better outcomes, whereas the opposite was true for the oropharyngeal lateral walls. This study suggests that the role for DISE in counseling candidates for HNS extends beyond solely for excluding complete concentric collapse related to the velum. LEVEL OF EVIDENCE: 3 Laryngoscope, 131:1676-1682, 2021.

Indexed as

Hypoglossal NerveAgedAirway ObstructionContraindications, ProcedureCounselingElectric Stimulation TherapyEndoscopyFemaleHumansHypnotics and SedativesImplantable NeurostimulatorsMaleMiddle AgedOropharynxPalatePolysomnographyHypnotics and Sedativesdrug-induced sleep endoscopyHypoglossal nerve stimulationobstructive sleep apneaupper airway stimulation

Identifiers

PMID33443811
PMCPMC8362605
OpenAlexW3118427691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.