Evidence map›Paper›PMID 33443721›Full record

ReviewGlycoconjugate journal2021

40 years of glyco-polyacrylamide in glycobiology.

Alexander Tuzikov, Alexander Chinarev, Nadezhda Shilova, Elena Gordeeva, Oxana Galanina, Tatyana Ovchinnikova, Marcel Schaefer, Nicolai Bovin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Glycoconjugate journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Alexander TuzikovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
Alexander ChinarevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
Nadezhda ShilovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
Elena GordeevaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
Oxana GalaninaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
Tatyana OvchinnikovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
Marcel SchaeferCentre for Kode Technology Innovation, Auckland University of Technology, Auckland, 1010, New Zealand.
Nicolai BovinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia. professorbovin@yandex.ru.ORCID 0000-0001-8669-4477
Institute of Bioorganic Chemistry · RUAuckland University of Technology · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyacrylamide conjugates of glycans have long been widely used in many research areas of glycobiology, mainly for immobilizing glycans in solid-phase assays and as multivalent inhibitors. Pending biotin tag allows immobilizing Glyc-PAA quantitatively on any surface, and acts as a tracer for detection of carbohydrate-binding proteins. However, the scope of already realized capabilities of these probes is immeasurably richer than those listed above. This review is not so much about routine as about less common, but not less significant applications. Also, the data on the glycopolymers themselves, their molecular weight, size and polymer chain flexibility are presented, as well as the methods of synthesis, clusterisation and entropy factor in their interaction with proteins.

Indexed as

Acrylic ResinsBiotinGlycoconjugatesGlycomicsMolecular WeightOrthomyxoviridaePolyacrylamidesPolysaccharidesReproducibility of ResultsAcrylic ResinsBiotinGlycoconjugatesPolyacrylamidesPolysaccharidesEnd-biotinFluorescent probesGlycan-binding proteinsGlycansGlyco-clustersGlycopolymersGlyco-surfaceGlyc-PAAImmobilizationOligosaccharidesPAAPGASolid-phase assay

Identifiers

PMID33443721
OpenAlexW3119565936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.